Nature Communications (Feb 2023)
Sugar transporter Slc37a2 regulates bone metabolism in mice via a tubular lysosomal network in osteoclasts
- Pei Ying Ng,
- Amy B. P. Ribet,
- Qiang Guo,
- Benjamin H. Mullin,
- Jamie W. Y. Tan,
- Euphemie Landao-Bassonga,
- Sébastien Stephens,
- Kai Chen,
- Jinbo Yuan,
- Laila Abudulai,
- Maike Bollen,
- Edward T. T. T. Nguyen,
- Jasreen Kular,
- John M. Papadimitriou,
- Kent Søe,
- Rohan D. Teasdale,
- Jiake Xu,
- Robert G. Parton,
- Hiroshi Takayanagi,
- Nathan J. Pavlos
Affiliations
- Pei Ying Ng
- School of Biomedical Sciences, The University of Western Australia
- Amy B. P. Ribet
- School of Biomedical Sciences, The University of Western Australia
- Qiang Guo
- School of Biomedical Sciences, The University of Western Australia
- Benjamin H. Mullin
- School of Biomedical Sciences, The University of Western Australia
- Jamie W. Y. Tan
- School of Biomedical Sciences, The University of Western Australia
- Euphemie Landao-Bassonga
- School of Biomedical Sciences, The University of Western Australia
- Sébastien Stephens
- School of Medicine and Dentistry, Griffith University
- Kai Chen
- School of Biomedical Sciences, The University of Western Australia
- Jinbo Yuan
- School of Biomedical Sciences, The University of Western Australia
- Laila Abudulai
- School of Biomedical Sciences, The University of Western Australia
- Maike Bollen
- Centre for Microscopy, Analysis and Characterisation, The University of Western Australia
- Edward T. T. T. Nguyen
- School of Biomedical Sciences, The University of Western Australia
- Jasreen Kular
- School of Biomedical Sciences, The University of Western Australia
- John M. Papadimitriou
- PathWest Laboratory Medicine WA
- Kent Søe
- Pathology Research Unit, Department of Clinical Research, University of Southern Denmark
- Rohan D. Teasdale
- School of Biomedical Sciences, The University of Queensland
- Jiake Xu
- School of Biomedical Sciences, The University of Western Australia
- Robert G. Parton
- Institute for Molecular Bioscience, The University of Queensland
- Hiroshi Takayanagi
- Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo
- Nathan J. Pavlos
- School of Biomedical Sciences, The University of Western Australia
- DOI
- https://doi.org/10.1038/s41467-023-36484-2
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 23
Abstract
Despite the importance of osteoclast secretory lysosomes in bone digestion, the proteins that regulate them remain ill defined. Here, the authors identify Slc37a2 as a secretory lysosome sugar transporter that is required for maintenance of skeletal bone mass.
