mSphere (Oct 2021)
Sustained Replication of Synthetic Canine Distemper Virus Defective Genomes <i>In Vitro</i> and <i>In Vivo</i>
- Natasha L. Tilston-Lunel,
- Stephen R. Welch,
- Sham Nambulli,
- Rory D. de Vries,
- Gregory W. Ho,
- David E. Wentworth,
- Reed Shabman,
- Stuart T. Nichol,
- Christina F. Spiropoulou,
- Rik L. de Swart,
- Linda J. Rennick,
- W. Paul Duprex
Affiliations
- Natasha L. Tilston-Lunel
- ORCiD
- Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
- Stephen R. Welch
- ORCiD
- Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
- Sham Nambulli
- ORCiD
- Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
- Rory D. de Vries
- Department of Viroscience, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands
- Gregory W. Ho
- Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts, USA
- David E. Wentworth
- J. Craig Venter Institute, Rockville, Maryland, USA
- Reed Shabman
- J. Craig Venter Institute, Rockville, Maryland, USA
- Stuart T. Nichol
- Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
- Christina F. Spiropoulou
- ORCiD
- Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
- Rik L. de Swart
- ORCiD
- Department of Viroscience, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands
- Linda J. Rennick
- ORCiD
- Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
- W. Paul Duprex
- ORCiD
- Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
- DOI
- https://doi.org/10.1128/mSphere.00537-21
- Journal volume & issue
-
Vol. 6,
no. 5
Abstract
Defective interfering (DI) genomes have long been considered inconvenient artifacts that suppressed viral replication in vitro
