Functional roles of circular RNAs in lung injury

Fei-Fei Gao; Dian-Qing Chen; Yue-Tong Jiang; Cui-Fei Han; Bi-Yun Lin; Zhan Yang; Juan-Hua Quan; Ying-Huan Xiong; Xin-Tian Chen

doi:10.3389/fphar.2024.1354806

Frontiers in Pharmacology (Mar 2024)

Functional roles of circular RNAs in lung injury

Fei-Fei Gao,
Dian-Qing Chen,
Yue-Tong Jiang,
Cui-Fei Han,
Bi-Yun Lin,
Zhan Yang,
Juan-Hua Quan,
Ying-Huan Xiong,
Xin-Tian Chen

Affiliations

Fei-Fei Gao: Stem Cell Research and Cellular Therapy Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China
Dian-Qing Chen: Department of Hand and Foot Surgery, Armed Police Corps Hospital of Hebei, Shijiazhuang, Hebei, China
Yue-Tong Jiang: Guangdong Medical University, Zhanjiang, Guangdong, China
Cui-Fei Han: Guangdong Medical University, Zhanjiang, Guangdong, China
Bi-Yun Lin: Biotissue Repository, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China
Zhan Yang: Biotissue Repository, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China
Juan-Hua Quan: Laboratory of Gastroenterology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China
Ying-Huan Xiong: Biotissue Repository, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China
Xin-Tian Chen: Laboratory of Gastroenterology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China

DOI: https://doi.org/10.3389/fphar.2024.1354806
Journal volume & issue: Vol. 15

Abstract

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Lung injury leads to respiratory dysfunction, low quality of life, and even life-threatening conditions. Circular RNAs (circRNAs) are endogenous RNAs produced by selective RNA splicing. Studies have reported their involvement in the progression of lung injury. Understanding the roles of circRNAs in lung injury may aid in elucidating the underlying mechanisms and provide new therapeutic targets. Thus, in this review, we aimed to summarize and discuss the characteristics and biological functions of circRNAs, and their roles in lung injury from existing research, to provide a theoretical basis for the use of circRNAs as a diagnostic and therapeutic target for lung injury.

Published in Frontiers in Pharmacology

ISSN: 1663-9812 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://journal.frontiersin.org/journals/pharmacology

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Abstract

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