A natural BACE1 and GSK3β dual inhibitor Notopterol effectively ameliorates the cognitive deficits in APP/PS1 Alzheimer's mice by attenuating amyloid‐β and tau pathology

• Xiaowen Jiang,
• Hongyuan Lu,
• Jingda Li,
• Wenwu Liu,
• Qiong Wu,
• Zihua Xu,
• Qinglong Qiao,
• Haotian Zhang,
• Huiyuan Gao,
• Qingchun Zhao

Affiliations

Xiaowen Jiang

Key Laboratory of Structure‐Based Drug Design & Discovery Ministry of Education Shenyang Pharmaceutical University Shenyang People's Republic of China

Hongyuan Lu

School of Traditional Chinese Medicine Shenyang Pharmaceutical University Shenyang People's Republic of China

Jingda Li

Key Laboratory of Structure‐Based Drug Design & Discovery Ministry of Education Shenyang Pharmaceutical University Shenyang People's Republic of China

Wenwu Liu

Key Laboratory of Structure‐Based Drug Design & Discovery Ministry of Education Shenyang Pharmaceutical University Shenyang People's Republic of China

Qiong Wu

Department of Pharmacy General Hospital of Northern Theater Command Shenyang People's Republic of China

Zihua Xu

Department of Pharmacy General Hospital of Northern Theater Command Shenyang People's Republic of China

Qinglong Qiao

Key Laboratory of Separation Science for Analytical Chemistry Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian People's Republic of China

Haotian Zhang

School of Life Sciences Shenyang Pharmaceutical University Shenyang People's Republic of China

Huiyuan Gao

Key Laboratory of Structure‐Based Drug Design & Discovery Ministry of Education Shenyang Pharmaceutical University Shenyang People's Republic of China

Qingchun Zhao

Key Laboratory of Structure‐Based Drug Design & Discovery Ministry of Education Shenyang Pharmaceutical University Shenyang People's Republic of China