Vertebrate myosin 1d regulates left–right organizer morphogenesis and laterality

Manush Saydmohammed; Hisato Yagi; Michael Calderon; Madeline J. Clark; Timothy Feinstein; Ming Sun; Donna B. Stolz; Simon C. Watkins; Jeffrey D. Amack; Cecilia W. Lo; Michael Tsang

doi:10.1038/s41467-018-05866-2

Nature Communications (Aug 2018)

Vertebrate myosin 1d regulates left–right organizer morphogenesis and laterality

Manush Saydmohammed,
Hisato Yagi,
Michael Calderon,
Madeline J. Clark,
Timothy Feinstein,
Ming Sun,
Donna B. Stolz,
Simon C. Watkins,
Jeffrey D. Amack,
Cecilia W. Lo,
Michael Tsang

Affiliations

Manush Saydmohammed: Department of Developmental Biology, University of Pittsburgh
Hisato Yagi: Department of Developmental Biology, University of Pittsburgh
Michael Calderon: Department of Cell Biology, University of Pittsburgh
Madeline J. Clark: Department of Cell and Developmental Biology, State University of New York Upstate Medical University
Timothy Feinstein: Department of Developmental Biology, University of Pittsburgh
Ming Sun: Department of Cell Biology, University of Pittsburgh
Donna B. Stolz: Department of Cell Biology, University of Pittsburgh
Simon C. Watkins: Department of Cell Biology, University of Pittsburgh
Jeffrey D. Amack: Department of Cell and Developmental Biology, State University of New York Upstate Medical University
Cecilia W. Lo: Department of Developmental Biology, University of Pittsburgh
Michael Tsang: Department of Developmental Biology, University of Pittsburgh

DOI: https://doi.org/10.1038/s41467-018-05866-2
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 11

Abstract

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The actin-based motor Myosin1d is needed to establish left–right asymmetry in Drosophila. Here the authors show that myosin 1d has a role in lumen formation, vacuole trafficking and left-right asymmetry establishment during zebrafish development.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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