Nature Communications (Jun 2022)
The androgen receptor is a therapeutic target in desmoplastic small round cell sarcoma
- Salah-Eddine Lamhamedi-Cherradi,
- Mayinuer Maitituoheti,
- Brian A. Menegaz,
- Sandhya Krishnan,
- Amelia M. Vetter,
- Pamela Camacho,
- Chia-Chin Wu,
- Hannah C. Beird,
- Robert W. Porter,
- Davis R. Ingram,
- Vandhana Ramamoorthy,
- Sana Mohiuddin,
- David McCall,
- Danh D. Truong,
- Branko Cuglievan,
- P. Andrew Futreal,
- Alejandra Ruiz Velasco,
- Nazanin Esmaeili Anvar,
- Budi Utama,
- Mark Titus,
- Alexander J. Lazar,
- Wei-Lien Wang,
- Cristian Rodriguez-Aguayo,
- Ravin Ratan,
- J. Andrew Livingston,
- Kunal Rai,
- A. Robert MacLeod,
- Najat C. Daw,
- Andrea Hayes-Jordan,
- Joseph A. Ludwig
Affiliations
- Salah-Eddine Lamhamedi-Cherradi
- Sarcoma Medical Oncology Department, The University of Texas MD Anderson Cancer Center
- Mayinuer Maitituoheti
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Brian A. Menegaz
- Department of Surgery, Breast surgical Oncology, Baylor College of Medicine
- Sandhya Krishnan
- Sarcoma Medical Oncology Department, The University of Texas MD Anderson Cancer Center
- Amelia M. Vetter
- Sarcoma Medical Oncology Department, The University of Texas MD Anderson Cancer Center
- Pamela Camacho
- Texas Children’s Cancer & Hematology Centers
- Chia-Chin Wu
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Hannah C. Beird
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Robert W. Porter
- Sarcoma Medical Oncology Department, The University of Texas MD Anderson Cancer Center
- Davis R. Ingram
- Division of Pathology, The University of Texas MD Anderson Cancer Center
- Vandhana Ramamoorthy
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Sana Mohiuddin
- Division of Pediatrics, The University of Texas MD Anderson Cancer Center
- David McCall
- Division of Pediatrics, The University of Texas MD Anderson Cancer Center
- Danh D. Truong
- Sarcoma Medical Oncology Department, The University of Texas MD Anderson Cancer Center
- Branko Cuglievan
- Division of Pediatrics, The University of Texas MD Anderson Cancer Center
- P. Andrew Futreal
- Division of Pathology, The University of Texas MD Anderson Cancer Center
- Alejandra Ruiz Velasco
- Sarcoma Medical Oncology Department, The University of Texas MD Anderson Cancer Center
- Nazanin Esmaeili Anvar
- Division of Pathology, The University of Texas MD Anderson Cancer Center
- Budi Utama
- Optical Microscopy Facility, Rice University
- Mark Titus
- Genitourinary Medical Oncology Department, The University of Texas MD Anderson Cancer Center
- Alexander J. Lazar
- Division of Pathology, The University of Texas MD Anderson Cancer Center
- Wei-Lien Wang
- Division of Pathology, The University of Texas MD Anderson Cancer Center
- Cristian Rodriguez-Aguayo
- Experimental Therapeutics Department, The University of Texas MD Anderson Cancer Center
- Ravin Ratan
- Sarcoma Medical Oncology Department, The University of Texas MD Anderson Cancer Center
- J. Andrew Livingston
- Sarcoma Medical Oncology Department, The University of Texas MD Anderson Cancer Center
- Kunal Rai
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- A. Robert MacLeod
- Ionis Pharmaceuticals
- Najat C. Daw
- Division of Pediatrics, The University of Texas MD Anderson Cancer Center
- Andrea Hayes-Jordan
- Lineberger Comprehensive Cancer Center, UNC
- Joseph A. Ludwig
- Sarcoma Medical Oncology Department, The University of Texas MD Anderson Cancer Center
- DOI
- https://doi.org/10.1038/s41467-022-30710-z
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
Androgen receptor can promote tumour progression in desmoplastic small round cell tumour (DSRCT), an aggressive paediatric malignancy that predominantly affects young males. Here, the authors show that DSRCT is an AR-driven malignancy and sensitive to androgen deprivation therapy
