Cell specific photoswitchable agonist for reversible control of endogenous dopamine receptors

Prashant Donthamsetti; Nils Winter; Adam Hoagland; Cherise Stanley; Meike Visel; Stephan Lammel; Dirk Trauner; Ehud Isacoff

doi:10.1038/s41467-021-25003-w

Nature Communications (Aug 2021)

Cell specific photoswitchable agonist for reversible control of endogenous dopamine receptors

Prashant Donthamsetti,
Nils Winter,
Adam Hoagland,
Cherise Stanley,
Meike Visel,
Stephan Lammel,
Dirk Trauner,
Ehud Isacoff

Affiliations

Prashant Donthamsetti: Molecular and Cell Biology, University of California, Berkeley
Nils Winter: Department of Chemistry, Ludwig-Maximilians University
Adam Hoagland: Molecular and Cell Biology, University of California, Berkeley
Cherise Stanley: Molecular and Cell Biology, University of California, Berkeley
Meike Visel: Molecular and Cell Biology, University of California, Berkeley
Stephan Lammel: Molecular and Cell Biology, University of California, Berkeley
Dirk Trauner: Department of Chemistry, New York University
Ehud Isacoff: Molecular and Cell Biology, University of California, Berkeley

DOI: https://doi.org/10.1038/s41467-021-25003-w
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

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In this study, the authors develop a photo-pharmacological strategy using a Membrane anchored Photoswitchable orthogonal remotely tethered agonist for the Dopamine receptor (MP-D) to selectively and reversibly modulate the D1R receptor subtype.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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