One-Pot Synthesis of Triazolobenzodiazepines Through Decarboxylative [3 + 2] Cycloaddition of Nonstabilized Azomethine Ylides and Cu-Free Click Reactions
Xiaoming Ma,
Xiaofeng Zhang,
Weiqi Qiu,
Wensheng Zhang,
Bruce Wan,
Jason Evans,
Wei Zhang
Affiliations
Xiaoming Ma
School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou 213164, China
Xiaofeng Zhang
Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Boulevard, Boston, MA 02125, USA
Weiqi Qiu
Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Boulevard, Boston, MA 02125, USA
Wensheng Zhang
School of Science, Jiaozuo Teachers’ College, 998 Shanyang Road, Jiaozuo 454100, China
Bruce Wan
Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Boulevard, Boston, MA 02125, USA
Jason Evans
Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Boulevard, Boston, MA 02125, USA
Wei Zhang
Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Boulevard, Boston, MA 02125, USA
A one-pot synthesis of triazolobenzodiazepine-containing polycyclic compounds is introduced. The reaction process involves a decarboxylative three-component [3 + 2] cycloaddition of nonstabilized azomethine ylides, N-propargylation, and intramolecular click reactions.
