The Journal of Qazvin University of Medical Sciences (Feb 2016)

Salivary lipid peroxidation in patients with oral lichen planus

  • M. Shirzaii,
  • F. Neshat,
  • AR. Nakhaee

Journal volume & issue
Vol. 19, no. 6
pp. 37 – 42

Abstract

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Background: Oral Lichen Planus (OLP) is an inflammatory condition with unknown etiology. Reactive oxygen species (ROS) and free radicals may play an important role in the pathogenesis of this disease. Objective: The aim of this study was to compare salivary lipid peroxidation in patients with oral lichen planus with healthy subjects. Methods: This case-control study was conducted in Zahedan School of Dentistry during 2014-15. Unstimulated saliva samples were collected from 30 patients with OLP and 30 age and gender-matched healthy controls and were transferred to the laboratory. Salivary lipid peroxidation products were measured using TBARS (thiobarbituric acid reactive substance) method. Data were analyzed using Mann-Whitney U test. Findings: Salivary lipid peroxidation in patients with OLP was significantly higher than healthy controls (1.57±0.63 μM vs. 1.2±0.77μM). Mean Salivary lipid peroxidation in women with OLP was significantly higher than healthy women (1.67±0.67 μM vs. 1.16±0.82 μM). Conclusion: With regards to the results, it seems that lipid peroxidation in patients with OLP is higher than healthy subjects.

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