A case of genital pyoderma gangrenosum successfully treated with cyclosporine without relapse of established follicular lymphoma

Abstract

Management of pyoderma gangrenosum in established malignancy is challenging. When vital structures are at risk from ulceration, aggressive management is required; however, immunosuppressive therapy may compromise the prognosis for an underlying malignancy. The optimal management of pyoderma gangrenosum in this setting is unclear. We report on a 64-year-old woman with follicular lymphoma in partial remission, who had severe genital pyoderma gangrenosum. After multidisciplinary evaluation, she was treated with corticosteroids and cyclosporine and healed fully with scarring over 7 weeks. She has required low-dose cyclosporine for 3 years to maintain remission of her genital ulceration; however, she remains well with no relapse of her lymphoma on serial imaging.