Pharmaceutics (Sep 2018)

Thermo-Sensitive Vesicles in Controlled Drug Delivery for Chemotherapy

  • Elisabetta Mazzotta,
  • Lorena Tavano,
  • Rita Muzzalupo

DOI
https://doi.org/10.3390/pharmaceutics10030150
Journal volume & issue
Vol. 10, no. 3
p. 150

Abstract

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Thermo-sensitive vesicles are a promising tool for triggering the release of drugs to solid tumours when used in combination with mild hyperthermia. Responsivity to temperature makes them intelligent nanodevices able to provide a site-specific chemotherapy. Following a brief introduction concerning hyperthermia and its advantageous combination with vesicular systems, recent investigations on thermo-sensitive vesicles useful for controlled drug delivery in cancer treatment are reported in this review. In particular, the influence of bilayer composition on the in vitro and in vivo behaviour of thermo-sensitive formulations currently under investigation have been extensively explored.

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