Air-jet spun PHBV/PCL blend tissue engineering scaffolds exhibit improved mechanical properties and cell proliferation

Sumama Nuthana Kalva; Yogesh B. Dalvi; Noorunnisa Khanam P; Ruby Varghese; Imran Ahammed; Robin Augustine; Anwarul Hasan

Results in Materials (Sep 2023)

Air-jet spun PHBV/PCL blend tissue engineering scaffolds exhibit improved mechanical properties and cell proliferation

Sumama Nuthana Kalva,
Yogesh B. Dalvi,
Noorunnisa Khanam P,
Ruby Varghese,
Imran Ahammed,
Robin Augustine,
Anwarul Hasan

Affiliations

Sumama Nuthana Kalva: Department of Mechanical and Industrial Engineering, College of Engineering, Qatar University, PO Box 2713, Doha, Qatar; Biomedical Research Center (BRC), Qatar University, PO Box 2713, Doha, Qatar
Yogesh B. Dalvi: Pushpagiri Research Centre, Pushpagiri Institute of Medical Science & Research, Tiruvalla, Kerala, 689101, India
Noorunnisa Khanam P: Department of Mechanical and Industrial Engineering, College of Engineering, Qatar University, PO Box 2713, Doha, Qatar
Ruby Varghese: Pushpagiri Research Centre, Pushpagiri Institute of Medical Science & Research, Tiruvalla, Kerala, 689101, India; Department of Chemistry and Biochemistry, School of Sciences, Jain Deemed to be University, Bengaluru, Karnataka, 560027, India
Imran Ahammed: Rao′s Degree College, Yemmiganur, Andhra Pradesh, 518360, India
Robin Augustine: Department of Mechanical and Industrial Engineering, College of Engineering, Qatar University, PO Box 2713, Doha, Qatar; Biomedical Research Center (BRC), Qatar University, PO Box 2713, Doha, Qatar; Corresponding author. Department of Mechanical and Industrial Engineering, College of Engineering, Qatar University, PO Box 2713, Doha, Qatar.
Anwarul Hasan: Department of Mechanical and Industrial Engineering, College of Engineering, Qatar University, PO Box 2713, Doha, Qatar; Biomedical Research Center (BRC), Qatar University, PO Box 2713, Doha, Qatar; Corresponding author. Department of Mechanical and Industrial Engineering, College of Engineering, Qatar University, PO Box 2713, Doha, Qatar.

Journal volume & issue: Vol. 19
p. 100415

Abstract

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This study aimed to optimize the preparation parameters for air-jet spun blended poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and polycaprolactone (PCL) submicron fibrous scaffolds. Blends of PHBV and PCL were made using different weight ratios of polymers and examined for their mechanical, morphological, and biological properties. The 50/50 ratio PHBV/PCL blend scaffolds showed better overall mechanical properties compared to the scaffolds with higher PHBV content and provided better cell attachment and proliferation compared to PCL scaffolds. The incorporation of PCL improved the degree of crystallinity, thermal stability, and mechanical properties of PHBV/PCL blend scaffolds. In vivo subcutaneous implantation and subsequent histological analysis of the implanted scaffolds indicated that the scaffolds were compatible with animal tissues. The findings show that air-jet spun PHBV/PCL blended scaffolds in a 50/50 ratio can be employed in many tissue engineering applications.

Published in Results in Materials

ISSN: 2590-048X (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
Website: https://www.journals.elsevier.com/results-in-materials

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