Nature Communications (Aug 2019)
A conserved regulatory program initiates lateral plate mesoderm emergence across chordates
- Karin D. Prummel,
- Christopher Hess,
- Susan Nieuwenhuize,
- Hugo J. Parker,
- Katherine W. Rogers,
- Iryna Kozmikova,
- Claudia Racioppi,
- Eline C. Brombacher,
- Anna Czarkwiani,
- Dunja Knapp,
- Sibylle Burger,
- Elena Chiavacci,
- Gopi Shah,
- Alexa Burger,
- Jan Huisken,
- Maximina H. Yun,
- Lionel Christiaen,
- Zbynek Kozmik,
- Patrick Müller,
- Marianne Bronner,
- Robb Krumlauf,
- Christian Mosimann
Affiliations
- Karin D. Prummel
- Institute of Molecular Life Sciences, University of Zurich
- Christopher Hess
- Institute of Molecular Life Sciences, University of Zurich
- Susan Nieuwenhuize
- Institute of Molecular Life Sciences, University of Zurich
- Hugo J. Parker
- Department of Anatomy and Cell Biology, Kansas University Medical Center
- Katherine W. Rogers
- Friedrich Miescher Laboratory of the Max Planck Society
- Iryna Kozmikova
- Institute of Molecular Genetics of the ASCR
- Claudia Racioppi
- Center for Developmental Genetics, Department of Biology, New York University
- Eline C. Brombacher
- Institute of Molecular Life Sciences, University of Zurich
- Anna Czarkwiani
- TUD-CRTD Center for Regenerative Therapies Dresden
- Dunja Knapp
- TUD-CRTD Center for Regenerative Therapies Dresden
- Sibylle Burger
- Institute of Molecular Life Sciences, University of Zurich
- Elena Chiavacci
- Institute of Molecular Life Sciences, University of Zurich
- Gopi Shah
- Max Planck Institute of Molecular Cell Biology and Genetics
- Alexa Burger
- Institute of Molecular Life Sciences, University of Zurich
- Jan Huisken
- Max Planck Institute of Molecular Cell Biology and Genetics
- Maximina H. Yun
- TUD-CRTD Center for Regenerative Therapies Dresden
- Lionel Christiaen
- Center for Developmental Genetics, Department of Biology, New York University
- Zbynek Kozmik
- Institute of Molecular Genetics of the ASCR
- Patrick Müller
- Friedrich Miescher Laboratory of the Max Planck Society
- Marianne Bronner
- Division of Biology and Biological Engineering, California Institute of Technology
- Robb Krumlauf
- Department of Anatomy and Cell Biology, Kansas University Medical Center
- Christian Mosimann
- Institute of Molecular Life Sciences, University of Zurich
- DOI
- https://doi.org/10.1038/s41467-019-11561-7
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
Numerous tissues are derived from the lateral plate mesoderm (LPM) but how this is specified is unclear. Here, the authors identify a pan-LPM reporter activity found in the zebrafish draculin (drl) gene that also shows transgenic activity in LPM-corresponding territories of several chordates, including chicken, axolotl, lamprey, Ciona, and amphioxus.
