Neuropsychiatric Disease and Treatment (Oct 2022)

Prognostic Value of the Neutrophil-to-Lymphocyte Ratio in Patients with Chronic Internal Carotid Artery Occlusion Complicated by Cerebral Infarction

  • Qiu Z,
  • Guo T,
  • Sheng X,
  • Tang Y,
  • Du H

Journal volume & issue
Vol. Volume 18
pp. 2265 – 2271

Abstract

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Zhuoyin Qiu,1,2,* Tingting Guo,1,2,* Xihua Sheng,1,2 Ying Tang,1,2 Huaping Du1,2 1Department of Neurology, Suzhou Ninth People’s Hospital, Suzhou, People’s Republic of China; 2Department of Neurology, Suzhou Ninth Hospital Affiliated to Soochow University, Suzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Huaping Du, Department of Neurology, Suzhou Ninth People’s Hospital, No. 2666, Ludang Road, Wujiang District, Suzhou, Jiangsu, 215000, People’s Republic of China, Tel +86 512-82885052, Email [email protected]: This study aims to investigate the prognostic value of the peripheral neutrophil-to-lymphocyte ratio (NLR) in patients with chronic internal carotid artery occlusion (CICAO) complicated by cerebral infarction.Patients and Methods: The clinical data of 99 CICAO patients complicated by cerebral infarction were retrospectively analyzed. The modified Rankin Scale (mRS) was used to assess their 3-month prognosis, and a multivariate logistic regression model was established to explore risk factors for poor prognosis.Results: Multivariate logistic regression analysis demonstrated that NLR (OR=2.114; 95% CI: 1.129– 3.959) and baseline National Institute of Health Stroke Scale (NIHSS; OR=1.288, 95% CI: 1.053– 1.574) score were risk factors of poor prognosis. The area under the receiver operator characteristic (ROC) curve of NLR in predicting the 3-month outcome after onset was 0.717 (95% CI: 0.606– 0.828, P< 0.000). The optimal cut-off value was 3.22, with a sensitivity of 0.743 and a specificity of 0.791.Conclusion: NLR is an independent risk factor for the poor prognosis of CICAO patients complicated by cerebral infarction and can serve as an indicator for clinical prognosis.Keywords: chronic internal carotid artery occlusion, cerebral infarction, neutrophil-to-lymphocyte ratio, prognosis, predictive factors

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