Constitutive smooth muscle tumour necrosis factor regulates microvascular myogenic responsiveness and systemic blood pressure

Jeffrey T. Kroetsch; Andrew S. Levy; Hangjun Zhang; Roozbeh Aschar-Sobbi; Darcy Lidington; Stefan Offermanns; Sergei A. Nedospasov; Peter H. Backx; Scott P. Heximer; Steffen-Sebastian Bolz

doi:10.1038/ncomms14805

Nature Communications (Apr 2017)

Constitutive smooth muscle tumour necrosis factor regulates microvascular myogenic responsiveness and systemic blood pressure

Jeffrey T. Kroetsch,
Andrew S. Levy,
Hangjun Zhang,
Roozbeh Aschar-Sobbi,
Darcy Lidington,
Stefan Offermanns,
Sergei A. Nedospasov,
Peter H. Backx,
Scott P. Heximer,
Steffen-Sebastian Bolz

Affiliations

Jeffrey T. Kroetsch: Department of Physiology, Faculty of Medicine, University of Toronto, 1 King’s College Circle, Medical Sciences Building
Andrew S. Levy: Department of Physiology, Faculty of Medicine, University of Toronto, 1 King’s College Circle, Medical Sciences Building
Hangjun Zhang: Department of Physiology, Faculty of Medicine, University of Toronto, 1 King’s College Circle, Medical Sciences Building
Roozbeh Aschar-Sobbi: Division of Cardiology, University Health Network, R. Fraser Elliott Building
Darcy Lidington: Department of Physiology, Faculty of Medicine, University of Toronto, 1 King’s College Circle, Medical Sciences Building
Stefan Offermanns: Max-Planck-Institute for Heart and Lung Research
Sergei A. Nedospasov: Engelhardt Institute of Molecular Biology and Lemonosov Moscow State University
Peter H. Backx: Division of Cardiology, University Health Network, R. Fraser Elliott Building
Scott P. Heximer: Department of Physiology, Faculty of Medicine, University of Toronto, 1 King’s College Circle, Medical Sciences Building
Steffen-Sebastian Bolz: Department of Physiology, Faculty of Medicine, University of Toronto, 1 King’s College Circle, Medical Sciences Building

DOI: https://doi.org/10.1038/ncomms14805
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 14

Abstract

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TNF is typically viewed as an inflammatory mediator. Here the authors identify a non-inflammatory mechanism conserved across species whereby the constitutively expressed smooth muscle cell TNF mediates myogenic signal transduction in skeletal muscle resistance arteries and regulates mean arterial blood pressure.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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