Al-Mustansiriyah Journal of Pharmaceutical Sciences (Mar 2018)
Antibacterial Activity ofMiswak(SalvadorapersicaL.)Stem Aqueous and Ethanolic Extracts in vitro
Abstract
The aim was to evaluate the in vitro antibacterial activity of three concentrations (50, 75 and 100 μg/ml) of aqueous and ethanoliccrudeextractsofmiswak(Salvadorapersica) on threepathogenic bacteria (Staphylococcus aureus, Streptococcus pyogenesand Pseudomonas aeruginosa)using agar well-diffusion method.Phytochemical analysis revealed that the extracts contained alkaloids, flavonoids, phenols, tannins and steroids. Antibacterial evaluations demonstrated that both extracts inhibited the growth of the investigated bacteria in a concentration-dependent manner, but the aqueous extract was more efficient than the ethanolicextract.Thehighest growth-inhibition (GI) zone(22.1± 2.3mm)was observed in the culture ofP. aeruginosaat the concentration 100 μg/mlof the aqueous extract, while the lowest (12.3± 1.2 mm) was inthe culture of S.aureus using the ethanolic extract at the concentration 50 μg/ml. These findings suggest the antibacterial potential of Salvadorapersica stem, which might be related to its chemical constituents..
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