Journal of Ayurveda (Jan 2023)
Influence of mandukaparni targeting muscarinic acetylcholine receptor m1 in the management of Alzheimer's Disease: A network pharmacological approach
Abstract
Introduction: Mandukaparni, being one of the medhya rasayanas, has shown remarkable therapeutic effects in the management of psychological disorders. Network pharmacology is the latest scientific collaboration where new drug actions can be established with the help of computers. Here is an attempt to scientifically substantiate this action through network pharmacology which deals with ligand-target interaction. Here is an attempt to prove the therapeutic effect of Mandukaparni in memory enhancement by network pharmacology. We have also worked upon molecular docking if these phytochemicals to demonstrate the probable bonding energy scores for molecular docking. Methods: (1) Phytochemicals of Mandukaparni are collected from Dr. Duke's Phytochemical database. (2) The targets of these phytochemicals are derived from the ChemBL database. (3) Relation between the memory enhancement effect of these targets is ruled out by confirming the action of these targets on diseases such as Alzheimer's disease (AD). (4) The conclusion is derived from network pharmacological target ligand interaction. (5) Molecular docking is done to derive the pictorial representation of Protein-ligand interaction. Results: Phytochemicals such as quercetin, ascorbic acid, zinc, kaempferol, magnesium, limonene, selenium, beta-carotene, linalool, beta-sitosterol, niacin, geraniol, and thiamine were found to be targeting Muscarinic acetylcholine receptor M1 and were eventually found to be having therapeutic action on AD. The receptor protein Muscarinic acetylcholine receptor M1 was successfully docked with ascorbic acid, niacin, and kaempferol. Conclusion: Mandukaparni was found to be pharmacologically effective with all the phytochemicals targeting Muscarinic acetylcholine receptor M1 which is crucial in the management of AD.
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