Breast Cancer: Targets and Therapy (Apr 2021)
Jawbone Cavitation Expressed RANTES/CCL5: Case Studies Linking Silent Inflammation in the Jawbone with Epistemology of Breast Cancer
Abstract
Johann Lechner,1 Tilman Schulz,2 Beatrice Lejeune,3 Volker von Baehr4 1Clinic Integrative Dentistry Munich, Munich, Germany; 2Klinikum Bayreuth, Bayreuth, Germany; 3Labo’Life France, Nantes, France; 4Institute for Medical Diagnostics, Berlin, GermanyCorrespondence: Johann LechnerClinic Integrative Dentistry Munich, Praxisklinik Gruenwalder Str. 10A, Munich, 81547, GermanyTel +49 89 6970129Fax +49 89 6925830Email [email protected]: The role of signaling pathways as part of the cell-cell communication within cancer progression becomes a crucial area. Chemokine RANTES (regulated upon activation, normal T-cell expressed and secreted), also known as the chemokine C-C motif ligand 5 (CCL5) (R/C), is a protein on which cancer research focus due to its link with aggressive cancer development.Objective: Research on fatty-degenerative osteonecrosis in jawbone (FDOJ) shows striking overexpression of R/C in these areas. Here we try to elucidate a potential link between jawbone-derived R/C and breast cancer (BC) and compare these findings by immunohistochemical staining.Methods: Thirty-nine FDOJ samples extracted from 39 BC patients and samples from 19 healthy control were analyzed for R/C expression using bead-based Luminex® analysis. R/C levels from 5 BC patients were measured in serum before and after FDOJ surgery. Bone density, histology, R/C expression, and immunohistochemistry were analysed in 4 clinical case studies. The R/C staining of two FDOJ BC patients is compared with the immunohistochemical staining of BC cell preparations.Results: A high overexpression of R/C was seen in all FDOJ samples. R/C levels in serum were statistically downregulated after FDOJ surgery (p=0.0241).Discussion: R/C induced “silent inflammation” in BC is widely discussed in scientific papers along with R/C triggering of different signaling pathways, which might be a key point in the development of BC.Conclusion: Hypothesis that FDOJ may serve as a trigger of BC progression through R/C overexpression was set by the authors, who thus inspire clinicians to make aware of FDOJ throughout the dental and medical community in BC cases.Keywords: chemokine RANTES/CCL5, osteonecrosis of the jawbone, breast cancer, bead-based Luminex® analysis, hyperactivated signaling pathways
