Adrenergic-mediated loss of splenic marginal zone B cells contributes to infection susceptibility after stroke

Laura McCulloch; Craig J. Smith; Barry W. McColl

doi:10.1038/ncomms15051

Nature Communications (Apr 2017)

Adrenergic-mediated loss of splenic marginal zone B cells contributes to infection susceptibility after stroke

Laura McCulloch,
Craig J. Smith,
Barry W. McColl

Affiliations

Laura McCulloch: The Roslin Institute and R(D)SVS, University of Edinburgh, Easter Bush
Craig J. Smith: Stroke and Vascular Research Centre, University of Manchester, Manchester Academic Health Science Centre
Barry W. McColl: The Roslin Institute and R(D)SVS, University of Edinburgh, Easter Bush

DOI: https://doi.org/10.1038/ncomms15051
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 16

Abstract

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Risk of infection is high after stroke, but the causes are not clear. Here the authors implicate altered beta–adrenergic signalling after stroke that results in a reduction in IgM-mediated protection by marginal zone B cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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