Nature Communications (Jan 2020)
Cancer-associated fibroblast heterogeneity in axillary lymph nodes drives metastases in breast cancer through complementary mechanisms
- Floriane Pelon,
- Brigitte Bourachot,
- Yann Kieffer,
- Ilaria Magagna,
- Fanny Mermet-Meillon,
- Isabelle Bonnet,
- Ana Costa,
- Anne-Marie Givel,
- Youmna Attieh,
- Jorge Barbazan,
- Claire Bonneau,
- Laetitia Fuhrmann,
- Stéphanie Descroix,
- Danijela Vignjevic,
- Pascal Silberzan,
- Maria Carla Parrini,
- Anne Vincent-Salomon,
- Fatima Mechta-Grigoriou
Affiliations
- Floriane Pelon
- Institut Curie, Stress and Cancer Laboratory, Equipe labélisée par la Ligue Nationale contre le Cancer, PSL Research University
- Brigitte Bourachot
- Institut Curie, Stress and Cancer Laboratory, Equipe labélisée par la Ligue Nationale contre le Cancer, PSL Research University
- Yann Kieffer
- Institut Curie, Stress and Cancer Laboratory, Equipe labélisée par la Ligue Nationale contre le Cancer, PSL Research University
- Ilaria Magagna
- Institut Curie, Stress and Cancer Laboratory, Equipe labélisée par la Ligue Nationale contre le Cancer, PSL Research University
- Fanny Mermet-Meillon
- Analysis of Transduction Pathway, Institut Curie, Inserm, U830, PSL Research University
- Isabelle Bonnet
- Institut Curie, Biology-inspired Physics at MesoScales Laboratory, Equipe labélisée par la Ligue Nationale contre le Cancer, CNRS UMR168, PSL Research University, Sorbonne Université
- Ana Costa
- Institut Curie, Stress and Cancer Laboratory, Equipe labélisée par la Ligue Nationale contre le Cancer, PSL Research University
- Anne-Marie Givel
- Institut Curie, Stress and Cancer Laboratory, Equipe labélisée par la Ligue Nationale contre le Cancer, PSL Research University
- Youmna Attieh
- Institut Curie, Cell Migration and Invasion, UMR144, PSL Research University
- Jorge Barbazan
- Institut Curie, Cell Migration and Invasion, UMR144, PSL Research University
- Claire Bonneau
- Institut Curie, Stress and Cancer Laboratory, Equipe labélisée par la Ligue Nationale contre le Cancer, PSL Research University
- Laetitia Fuhrmann
- Department of Pathology, Institut Curie Hospital
- Stéphanie Descroix
- Institut Curie, Laboratoire Physico Chimie Curie, Institut Pierre-Gilles de Gennes, CNRS UMR168
- Danijela Vignjevic
- Institut Curie, Cell Migration and Invasion, UMR144, PSL Research University
- Pascal Silberzan
- Institut Curie, Biology-inspired Physics at MesoScales Laboratory, Equipe labélisée par la Ligue Nationale contre le Cancer, CNRS UMR168, PSL Research University, Sorbonne Université
- Maria Carla Parrini
- Analysis of Transduction Pathway, Institut Curie, Inserm, U830, PSL Research University
- Anne Vincent-Salomon
- Department of Pathology, Institut Curie Hospital
- Fatima Mechta-Grigoriou
- Institut Curie, Stress and Cancer Laboratory, Equipe labélisée par la Ligue Nationale contre le Cancer, PSL Research University
- DOI
- https://doi.org/10.1038/s41467-019-14134-w
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 20
Abstract
Cancer associated fibroblasts are known to promote the progression of cancer. Here, the authors show that two particular subsets of cancer associated fibroblasts induce metastasis but work via distinct mechanisms including, chemokine signalling and Notch signalling.
