Potential Biological Roles of Exosomal Long Non-Coding RNAs in Gastrointestinal Cancer

Fanhua Kang; Feng Jiang; Lingzi Ouyang; Shangjun Wu; Chencheng Fu; Ying Liu; Zhilan Li; Yu Tian; Xiaolan Cao; Xiaoping Wang; Qingchun He; Qingchun He; Qingchun He

doi:10.3389/fcell.2022.886191

Frontiers in Cell and Developmental Biology (May 2022)

Potential Biological Roles of Exosomal Long Non-Coding RNAs in Gastrointestinal Cancer

Fanhua Kang,
Feng Jiang,
Lingzi Ouyang,
Shangjun Wu,
Chencheng Fu,
Ying Liu,
Zhilan Li,
Yu Tian,
Xiaolan Cao,
Xiaoping Wang,
Qingchun He,
Qingchun He,
Qingchun He

Affiliations

Fanhua Kang: Department of Pathology, Xiangya Changde Hospital, Changde, China
Feng Jiang: Department of Medicine, Xizang Minzu University, Xianyang, China
Lingzi Ouyang: Department of Pathology, Xiangya Changde Hospital, Changde, China
Shangjun Wu: Department of Pathology, Xiangya Changde Hospital, Changde, China
Chencheng Fu: Department of Pathology, Xiangya Changde Hospital, Changde, China
Ying Liu: Department of Pathology, Xiangya Changde Hospital, Changde, China
Zhilan Li: Department of Pathology, Xiangya Changde Hospital, Changde, China
Yu Tian: Department of Medicine, Xizang Minzu University, Xianyang, China
Xiaolan Cao: Department of Medicine, Xizang Minzu University, Xianyang, China
Xiaoping Wang: Department of Medicine, Xizang Minzu University, Xianyang, China
Qingchun He: Department of Emergency, Xiangya Hospital, Central South University, Changsha, China
Qingchun He: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Qingchun He: Department of Emergency, Xiangya Changde Hospital, Changde, China

DOI: https://doi.org/10.3389/fcell.2022.886191
Journal volume & issue: Vol. 10

Abstract

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Exosomes, a type of extracellular vesicles (EVs), are secreted by almost all cells and contain many cellular constituents, such as nucleic acids, lipids, and metabolites. In addition, they play a crucial role in intercellular communication and have been proved to be involved in the development and treatment of gastrointestinal cancer. It has been confirmed that long non-coding RNAs (lncRNAs) exert a range of biological functions, such as cell metastasis, tumorigenesis, and therapeutic responses. This review mainly focused on the emerging roles and underlying molecular mechanisms of exosome-derived lncRNAs in gastrointestinal cancer in recent years. The biological roles of exosomal lncRNAs in the pathogenesis and therapeutic responses of gastrointestinal cancers were also investigated.

Published in Frontiers in Cell and Developmental Biology

ISSN: 2296-634X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.frontiersin.org/journals/cell-and-developmental-biology

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