Differential recognition of canonical NF-κB dimers by Importin α3

Tyler J. Florio; Ravi K. Lokareddy; Daniel P. Yeggoni; Rajeshwer S. Sankhala; Connor A. Ott; Richard E. Gillilan; Gino Cingolani

doi:10.1038/s41467-022-28846-z

Nature Communications (Mar 2022)

Differential recognition of canonical NF-κB dimers by Importin α3

Tyler J. Florio,
Ravi K. Lokareddy,
Daniel P. Yeggoni,
Rajeshwer S. Sankhala,
Connor A. Ott,
Richard E. Gillilan,
Gino Cingolani

Affiliations

Tyler J. Florio: Department of Biochemistry and Molecular Biology, Thomas Jefferson University
Ravi K. Lokareddy: Department of Biochemistry and Molecular Biology, Thomas Jefferson University
Daniel P. Yeggoni: Department of Biochemistry and Molecular Biology, Thomas Jefferson University
Rajeshwer S. Sankhala: Center of Infectious Disease Research, Walter Reed Army Institute of Research
Connor A. Ott: Department of Biochemistry and Molecular Biology, Thomas Jefferson University
Richard E. Gillilan: Macromolecular Diffraction Facility, Cornell High Energy Synchrotron Source (MacCHESS), Cornell University
Gino Cingolani: Department of Biochemistry and Molecular Biology, Thomas Jefferson University

DOI: https://doi.org/10.1038/s41467-022-28846-z
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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Nuclear translocation of the p50/p65 heterodimer is essential for NF-κB signaling. Here, the authors identify a bipartite Nuclear Localization Signal in the NF-κB p50/p65 heterodimer that is recognized with high affinity by importin α3.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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