Ferulic Acid: A Natural Phenol That Inhibits Neoplastic Events through Modulation of Oncogenic Signaling
Hardeep Singh Tuli,
Ajay Kumar,
Seema Ramniwas,
Renuka Coudhary,
Diwakar Aggarwal,
Manoj Kumar,
Ujjawal Sharma,
Nidarshana Chaturvedi Parashar,
Shafiul Haque,
Katrin Sak
Affiliations
Hardeep Singh Tuli
Department of Biotechnology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala 133207, India
Ajay Kumar
Punjab Biotechnology Incubator (PBTI), Phase VIII, Mohali 160071, India
Seema Ramniwas
University Centre for Research and Development, University Institute of Pharmaceutical Sciences, Chandigarh University, Gharuan, Mohali 140413, India
Renuka Coudhary
Department of Biotechnology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala 133207, India
Diwakar Aggarwal
Department of Biotechnology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala 133207, India
Manoj Kumar
Department of Chemistry, Maharishi Markandeshwar University, Sadopur-Ambala 134007, India
Ujjawal Sharma
Department of Human Genetics and Molecular Medicine, Central University of Punjab, Bhatinda 151001, India
Nidarshana Chaturvedi Parashar
Department of Biotechnology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala 133207, India
Shafiul Haque
Research and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University, Jazan 45142, Saudi Arabia
Despite the immense therapeutic advances in the field of health sciences, cancer is still to be found among the global leading causes of morbidity and mortality. Ethnomedicinally, natural bioactive compounds isolated from various plant sources have been used for the treatment of several cancer types and have gained notable attention. Ferulic acid, a natural compound derived from various seeds, nuts, leaves, and fruits, exhibits a variety of pharmacological effects in cancer, including its proapoptotic, cell-cycle-arresting, anti-metastatic, and anti-inflammatory activities. This review study presents a thorough overview of the molecular targets and cellular signaling pathways modulated by ferulic acid in diverse malignancies, showing high potential for this phenolic acid to be developed as a candidate agent for novel anticancer therapeutics. In addition, current investigations to develop promising synergistic formulations are also discussed.
