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Expression of B-cell activating factor, a proliferating inducing ligand and its receptors in primary central nervous system lymphoma

Neurology International. 2013;5(1):e4-e4 DOI 10.4081/ni.2013.e4


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Journal Title: Neurology International

ISSN: 2035-8385 (Print); 2035-8377 (Online)

Publisher: PAGEPress Publications

LCC Subject Category: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system

Country of publisher: Italy

Language of fulltext: English

Full-text formats available: PDF, HTML



Tobias Birnbaum (Department of Neurology, Ludwig-Maximilians University, Munich)

Sigrid Langer (Department of Neurology, Ludwig-Maximilians University, Munich)

Sigrun Roeber (Department of Neuropathology, Ludwig-Maximilians University, Munich)

Louisa von Baumgarten (Department of Neurology, Ludwig-Maximilians University, Munich)

Andreas Straube (Department of Neurology, Ludwig-Maximilians University, Munich)


Blind peer review

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Time From Submission to Publication: 10 weeks


Abstract | Full Text

B-cell activating factor belonging to the tumor necrosis factor family (BAFF) and a proliferating inducing ligand (APRIL) might play an important role in the pathogenesis of systemic B-cell malignancies. However, the BAFF/APRIL system has not been systematically evaluated in primary central nervous system lymphoma (PCNSL) to date. We assessed the expression of BAFF, APRIL and its receptors BAFF-R (BAFF receptor), BCMA (B-cell maturation antigen) and TACI (transmembrane activator and calcium modulator cyclophilin ligand interactor) in five PCNSL specimens by immunohistochemical staining. We found extensive expression of BAFF and weak to moderate expression of APRIL, BAFF-R, BCMA, and TACI in all specimens. CD20 positive cells showed expression of both ligands and receptors at the same time. Our results indicate that autocrine stimulation of the BAFF/APRIL system might be involved in the pathogenesis of PCNSL.