International Journal of Nanomedicine (Apr 2018)
Dual-responsive dithio-polydopamine coated porous CeO2 nanorods for targeted and synergistic drug delivery
Abstract
Ying Zhang,1,* Xiaowen Wu,1,* Chenxi Hou,1 Kun Shang,1 Kui Yang,1 Zhimin Tian,2 Zhichao Pei,1 Yongquan Qu,2 Yuxin Pei1 1Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry and Pharmacy, Northwest A&F University, Yangling, Shaanxi, People’s Republic of China; 2Center for Applied Chemical Research, Frontier Institute of Science and Technology, Xi’an Jiaotong University, Xi’an, People’s Republic of China *These authors contributed equally to this work Objective: The aim was to produce the first report of assembling degradable stimuli-responsive dithio-polydopamine coating with a cancer target unit for synergistic and targeted drug delivery. Methods: A multifunctional drug delivery system was constructed by coating a dual-responsive dithio-polydopamine (PDS) on porous CeO2 nanorods and subsequent conjugation of lactose derivative, where the PDS was formed by self-polymerization of dithio-dopamine (DOPASS). Results: The multifunctional drug delivery system displayed excellent cancer targeted ability resulting from the conjugation of lactose derivative, which could specifically recognize the overexpressed asialoglycoprotein receptors on the surface of HepG2 cells. It also showed a dual-responsive property of glutathione and pH, achieving controllable drug release from the cleavage of disulfide bond and subsequent degradation of PDS in cancer cells. Moreover, the degradation of PDS led to the exposure of CeO2 nanorods, which has a synergistic anticancer effect due to its cytotoxicity to cancer cells. Conclusion: This work presents a good example of a rational design towards synergistic and targeted DDS for cancer chemotherapies. Keywords: degradable polydopamine, cerium oxide nanoparticles, dual-responsiveness, targeted drug delivery, synergistic anticancer
