Tailoring antituberculosis treatment regimen in a patient with serious adverse drug reactions to multiple drugs

Abstract

Stevens–Johnson syndrome (SJS) and hepatitis are serious adverse drug reactions following the administration of anti-tuberculosis treatment (ATT). Here, we report a case of a young woman who developed hepatitis and SJS following ATT. Identifying the culprit drug and tailoring the appropriate regimen is a challenge to the clinicians. We described the clinical features, laboratory findings, hospital course and follow-up in a young female with tuberculosis, SJS and hepatitis in the case report. After the resolution of hepatitis, we confirmed the diagnosis of extrapulmonary tuberculosis and treated her after a cautious rechallenge with antitubercular drugs.

Keywords

• tuberculosis
• treatment
• hepatitis
• stevens–johnson syndrome