Frontiers in Physiology (Dec 2012)

Modulation of Myocardial Contraction by Peroxynitrite

  • Mark eKohr,
  • Steve eRoof,
  • Jay eZweier,
  • Mark T Ziolo

DOI
https://doi.org/10.3389/fphys.2012.00468
Journal volume & issue
Vol. 3

Abstract

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Peroxynitrite is a potent oxidant that is quickly emerging as a crucial modulator of myocardial function. This review will focus on the regulation of myocardial contraction by peroxynitrite during health and disease, with a specific emphasis on cardiomyocyte Ca2+ handling, proposed signaling pathways, and protein end-targets.

Keywords