Functional cargos of exosomes derived from Flk-1+ vascular progenitors enable neurulation and ameliorate embryonic anomalies in diabetic pregnancy

Songying Cao; Yanqing Wu; E. Albert Reece; Cheng Xu; Wei-Bin Shen; Sunjay Kaushal; Peixin Yang

doi:10.1038/s42003-022-03614-3

Communications Biology (Jul 2022)

Functional cargos of exosomes derived from Flk-1+ vascular progenitors enable neurulation and ameliorate embryonic anomalies in diabetic pregnancy

Songying Cao,
Yanqing Wu,
E. Albert Reece,
Cheng Xu,
Wei-Bin Shen,
Sunjay Kaushal,
Peixin Yang

Affiliations

Songying Cao: Department of Obstetrics, Gynecology & Reproductive Sciences, University of Maryland School of Medicine
Yanqing Wu: Department of Obstetrics, Gynecology & Reproductive Sciences, University of Maryland School of Medicine
E. Albert Reece: Department of Obstetrics, Gynecology & Reproductive Sciences, University of Maryland School of Medicine
Cheng Xu: Department of Obstetrics, Gynecology & Reproductive Sciences, University of Maryland School of Medicine
Wei-Bin Shen: Department of Obstetrics, Gynecology & Reproductive Sciences, University of Maryland School of Medicine
Sunjay Kaushal: Department of Surgery, University of Maryland School of Medicine
Peixin Yang: Department of Obstetrics, Gynecology & Reproductive Sciences, University of Maryland School of Medicine

DOI: https://doi.org/10.1038/s42003-022-03614-3
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 16

Abstract

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A crosstalk among components of the endoderm, mesoderm and neuroectoderm via the growth factor FGF2 and Survivin-containing exosomes is essential for successful neurulation and is deregulated in diabetic pregnancy.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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