Nature Communications (Sep 2019)
An African Salmonella Typhimurium ST313 sublineage with extensive drug-resistance and signatures of host adaptation
- Sandra Van Puyvelde,
- Derek Pickard,
- Koen Vandelannoote,
- Eva Heinz,
- Barbara Barbé,
- Tessa de Block,
- Simon Clare,
- Eve L. Coomber,
- Katherine Harcourt,
- Sushmita Sridhar,
- Emily A. Lees,
- Nicole E. Wheeler,
- Elizabeth J. Klemm,
- Laura Kuijpers,
- Lisette Mbuyi Kalonji,
- Marie-France Phoba,
- Dadi Falay,
- Dauly Ngbonda,
- Octavie Lunguya,
- Jan Jacobs,
- Gordon Dougan,
- Stijn Deborggraeve
Affiliations
- Sandra Van Puyvelde
- Department of Biomedical Sciences, Institute of Tropical Medicine
- Derek Pickard
- Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton
- Koen Vandelannoote
- Department of Biomedical Sciences, Institute of Tropical Medicine
- Eva Heinz
- Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton
- Barbara Barbé
- Department of Clinical Sciences, Institute of Tropical Medicine
- Tessa de Block
- Department of Biomedical Sciences, Institute of Tropical Medicine
- Simon Clare
- Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton
- Eve L. Coomber
- Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton
- Katherine Harcourt
- Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton
- Sushmita Sridhar
- Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton
- Emily A. Lees
- Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton
- Nicole E. Wheeler
- Centre for Genomic Pathogen Surveillance, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton
- Elizabeth J. Klemm
- Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton
- Laura Kuijpers
- Department of Clinical Sciences, Institute of Tropical Medicine
- Lisette Mbuyi Kalonji
- Department of Microbiology, National Institute for Biomedical Research
- Marie-France Phoba
- Department of Microbiology, National Institute for Biomedical Research
- Dadi Falay
- Department of Pediatrics, University Hospital of Kisangani
- Dauly Ngbonda
- Department of Pediatrics, University Hospital of Kisangani
- Octavie Lunguya
- Department of Microbiology, National Institute for Biomedical Research
- Jan Jacobs
- Department of Clinical Sciences, Institute of Tropical Medicine
- Gordon Dougan
- Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton
- Stijn Deborggraeve
- Department of Biomedical Sciences, Institute of Tropical Medicine
- DOI
- https://doi.org/10.1038/s41467-019-11844-z
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 12
Abstract
Invasive non-typhoidal Salmonella (iNTS) infections are dominated by antibiotic resistant isolates of the sequence type (ST) 313. Here, the authors identify the ST313 sublineage II.1 in the Democratic Republic of the Congo exhibiting extensive drug resistance and genetic signatures potentially associated with host adaptation.
