Patterned human microvascular grafts enable rapid vascularization and increase perfusion in infarcted rat hearts

Meredith A. Redd; Nicole Zeinstra; Wan Qin; Wei Wei; Amy Martinson; Yuliang Wang; Ruikang K. Wang; Charles E. Murry; Ying Zheng

doi:10.1038/s41467-019-08388-7

Nature Communications (Feb 2019)

Patterned human microvascular grafts enable rapid vascularization and increase perfusion in infarcted rat hearts

Meredith A. Redd,
Nicole Zeinstra,
Wan Qin,
Wei Wei,
Amy Martinson,
Yuliang Wang,
Ruikang K. Wang,
Charles E. Murry,
Ying Zheng

Affiliations

Meredith A. Redd: Department of Bioengineering, University of Washington
Nicole Zeinstra: Department of Bioengineering, University of Washington
Wan Qin: Department of Bioengineering, University of Washington
Wei Wei: Department of Bioengineering, University of Washington
Amy Martinson: Center for Cardiovascular Biology, University of Washington
Yuliang Wang: Institute for Stem Cell and Regenerative Medicine, University of Washington
Ruikang K. Wang: Department of Bioengineering, University of Washington
Charles E. Murry: Department of Bioengineering, University of Washington
Ying Zheng: Department of Bioengineering, University of Washington

DOI: https://doi.org/10.1038/s41467-019-08388-7
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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Heart grafts need good vascularization to survive. Here, the authors engineer perfusable constructs of human embryonic stem cell-derived endothelial cells seeded in collagen matrix in patterned microchannels that form anastomosed vessels in vitro and have increased coronary vascular perfusion on transplantation in rats.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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