Single cell RNA sequencing research in maternal fetal interface

Qian Chen; Qian Chen; Dan Shan; Dan Shan; Yupei Xie; Yupei Xie; Xingrong Luo; Xingrong Luo; Yuxia Wu; Yuxia Wu; Qiuhe Chen; Qiuhe Chen; Ruihong Dong; Ruihong Dong; Yayi Hu; Yayi Hu; Yayi Hu

doi:10.3389/fcell.2022.1079961

Frontiers in Cell and Developmental Biology (Jan 2023)

Single cell RNA sequencing research in maternal fetal interface

Qian Chen,
Qian Chen,
Dan Shan,
Dan Shan,
Yupei Xie,
Yupei Xie,
Xingrong Luo,
Xingrong Luo,
Yuxia Wu,
Yuxia Wu,
Qiuhe Chen,
Qiuhe Chen,
Ruihong Dong,
Ruihong Dong,
Yayi Hu,
Yayi Hu,
Yayi Hu

Affiliations

Qian Chen: Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, China
Qian Chen: Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China
Dan Shan: Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, China
Dan Shan: Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China
Yupei Xie: Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, China
Yupei Xie: Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China
Xingrong Luo: Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, China
Xingrong Luo: Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China
Yuxia Wu: Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, China
Yuxia Wu: Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China
Qiuhe Chen: Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, China
Qiuhe Chen: Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China
Ruihong Dong: Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, China
Ruihong Dong: Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China
Yayi Hu: Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, China
Yayi Hu: Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China
Yayi Hu: Qingbaijiang Maternal and Child Health Hospital, Chengdu, China

DOI: https://doi.org/10.3389/fcell.2022.1079961
Journal volume & issue: Vol. 10

Abstract

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The maternal-fetal interface is an essential environment for embryonic growth and development, and a successful pregnancy depends on the dynamic balance of the microenvironment at the maternal-fetal interface. Single-cell sequencing, which unlike bulk sequencing that provides averaged data, is a robust method for interpreting the cellular and molecular landscape at single-cell resolution. With the support of single-cell sequencing, the issue of maternal-fetal interface heterogeneity during pregnancy has been more deeply elaborated and understood, which is important for a deeper understanding of physiological and pathological pregnancy. In this paper, we analyze the recent studies of single-cell transcriptomics in the maternal-fetal interface, and provide new directions for understanding and treating various pathological pregnancies.

Published in Frontiers in Cell and Developmental Biology

ISSN: 2296-634X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.frontiersin.org/journals/cell-and-developmental-biology

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