Gsta4 controls apoptosis of differentiating adult oligodendrocytes during homeostasis and remyelination via the mitochondria-associated Fas-Casp8-Bid-axis

Karl E. Carlström; Keying Zhu; Ewoud Ewing; Inge E. Krabbendam; Robert A. Harris; Ana Mendanha Falcão; Maja Jagodic; Gonçalo Castelo-Branco; Fredrik Piehl

doi:10.1038/s41467-020-17871-5

Nature Communications (Aug 2020)

Gsta4 controls apoptosis of differentiating adult oligodendrocytes during homeostasis and remyelination via the mitochondria-associated Fas-Casp8-Bid-axis

Karl E. Carlström,
Keying Zhu,
Ewoud Ewing,
Inge E. Krabbendam,
Robert A. Harris,
Ana Mendanha Falcão,
Maja Jagodic,
Gonçalo Castelo-Branco,
Fredrik Piehl

Affiliations

Karl E. Carlström: Department of Clinical Neurosciences, Karolinska Institutet, Center for Molecular Medicine, Karolinska Hospital at Solna
Keying Zhu: Department of Clinical Neurosciences, Karolinska Institutet, Center for Molecular Medicine, Karolinska Hospital at Solna
Ewoud Ewing: Department of Clinical Neurosciences, Karolinska Institutet, Center for Molecular Medicine, Karolinska Hospital at Solna
Inge E. Krabbendam: Department of Clinical Neurosciences, Karolinska Institutet, Center for Molecular Medicine, Karolinska Hospital at Solna
Robert A. Harris: Department of Clinical Neurosciences, Karolinska Institutet, Center for Molecular Medicine, Karolinska Hospital at Solna
Ana Mendanha Falcão: Laboratory of Molecular Neurobiology, Department Medical Biochemistry and Biophysics, Biomedicum, Karolinska Institutet
Maja Jagodic: Department of Clinical Neurosciences, Karolinska Institutet, Center for Molecular Medicine, Karolinska Hospital at Solna
Gonçalo Castelo-Branco: Laboratory of Molecular Neurobiology, Department Medical Biochemistry and Biophysics, Biomedicum, Karolinska Institutet
Fredrik Piehl: Department of Clinical Neurosciences, Karolinska Institutet, Center for Molecular Medicine, Karolinska Hospital at Solna

DOI: https://doi.org/10.1038/s41467-020-17871-5
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 13

Abstract

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Impaired oligodendrocyte (OL) differentiation and remyelination after myelin damage in multiple sclerosis is associated with neurodegeneration. The authors show that Gsta4 is expressed during adult OL differentiation and identify it as a regulator of OL differentiation, survival, and remyelination.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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