Transneuronal delivery of hyper-interleukin-6 enables functional recovery after severe spinal cord injury in mice

Abstract

The CNS has limited ability to regenerate following injury, Here, the authors show that a single injection of AAV-hyper-interleukin-6 in the sensory motor cortex results in corticospinal and raphe spinal tracts regeneration in the injured spinal cord as well as functional recovery in mice.