Scientific Reports (Jun 2024)
Association of blood group O with a recurrent risk for acute lower gastrointestinal bleeding from a multicenter cohort study
- Sho Suzuki,
- Naoyuki Tominaga,
- Tomonori Aoki,
- Eiji Sadashima,
- Tadashi Miike,
- Hiroshi Kawakami,
- Katsumasa Kobayashi,
- Atsushi Yamauchi,
- Atsuo Yamada,
- Jun Omori,
- Takashi Ikeya,
- Taiki Aoyama,
- Yoshinori Sato,
- Takaaki Kishino,
- Naoki Ishii,
- Tsunaki Sawada,
- Masaki Murata,
- Akinari Takao,
- Kazuhiro Mizukami,
- Ken Kinjo,
- Shunji Fujimori,
- Takahiro Uotani,
- Minoru Fujita,
- Hiroki Sato,
- Toshiaki Narasaka,
- Junnosuke Hayasaka,
- Tomohiro Funabiki,
- Yuzuru Kinjo,
- Akira Mizuki,
- Shu Kiyotoki,
- Tatsuya Mikami,
- Ryosuke Gushima,
- Hiroyuki Fujii,
- Yuta Fuyuno,
- Takuto Hikichi,
- Yosuke Toya,
- Kazuyuki Narimatsu,
- Noriaki Manabe,
- Koji Nagaike,
- Tetsu Kinjo,
- Yorinobu Sumida,
- Sadahiro Funakoshi,
- Kiyonori Kobayashi,
- Tamotsu Matsuhashi,
- Yuga Komaki,
- Mitsuru Kaise,
- Naoyoshi Nagata
Affiliations
- Sho Suzuki
- Department of Gastroenterology and Hepatology, Center for Digestive Disease and Division of Endoscopy, University of Miyazaki Hospital
- Naoyuki Tominaga
- Department of Gastroenterology, Saga-Ken Medical Centre Koseikan
- Tomonori Aoki
- Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo
- Eiji Sadashima
- Department of Medical Research Institute, Saga-Ken Medical Centre Koseikan
- Tadashi Miike
- Department of Gastroenterology and Hepatology, Center for Digestive Disease and Division of Endoscopy, University of Miyazaki Hospital
- Hiroshi Kawakami
- Department of Gastroenterology and Hepatology, Center for Digestive Disease and Division of Endoscopy, University of Miyazaki Hospital
- Katsumasa Kobayashi
- Department of Gastroenterology, Tokyo Metropolitan Bokutoh Hospital
- Atsushi Yamauchi
- Department of Gastroenterology and Hepatology, Kitano Hospital, Tazuke Kofukai Medical Research Institute
- Atsuo Yamada
- Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo
- Jun Omori
- Department of Gastroenterology, Nippon Medical School, Graduate School of Medicine
- Takashi Ikeya
- Department of Gastroenterology, St Luke’s International University
- Taiki Aoyama
- Department of Gastroenterology, Hiroshima City Asa Citizens Hospital
- Yoshinori Sato
- Division of Gastroenterology, Department of Internal Medicine, St Marianna University School of Medicine
- Takaaki Kishino
- Department of Gastroenterology and Hepatology, Center for Digestive and Liver Diseases, Nara City Hospital
- Naoki Ishii
- Department of Gastroenterology, Tokyo Shinagawa Hospital
- Tsunaki Sawada
- Department of Endoscopy, Nagoya University Hospital
- Masaki Murata
- Department of Gastroenterology, National Hospital Organization Kyoto Medical Center
- Akinari Takao
- Department of Gastroenterology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital
- Kazuhiro Mizukami
- Department of Gastroenterology, Oita University
- Ken Kinjo
- Department of Gastroenterology, Fukuoka University Chikushi Hospital
- Shunji Fujimori
- Department of Gastroenterology, Chiba Hokusoh Hospital, Nippon Medical School
- Takahiro Uotani
- Department of Gastroenterology, Japanese Red Cross Shizuoka Hospital
- Minoru Fujita
- Division of Endoscopy and Ultrasonography, Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School General Medical Center
- Hiroki Sato
- Division of Gastroenterology, Graduate School of Medical and Dental Sciences, Niigata University
- Toshiaki Narasaka
- Department of Gastroenterology, University of Tsukuba
- Junnosuke Hayasaka
- Department of Gastroenterology, Toranomon Hospital
- Tomohiro Funabiki
- Department of Emergency Medicine, Fujita Health University Hospital
- Yuzuru Kinjo
- Department of Gastroenterology, Naha City Hospital
- Akira Mizuki
- Department of Internal Medicine, Tokyo Saiseikai Central Hospital
- Shu Kiyotoki
- Department of Gastroenterology, Shuto General Hospital
- Tatsuya Mikami
- Division of Endoscopy, Hirosaki University Hospital
- Ryosuke Gushima
- Department of Gastroenterology and Hepatology, Graduate School of Medical Sciences, Kumamoto University
- Hiroyuki Fujii
- Department of Gastroenterology and Hepatology, National Hospital Organization Fukuokahigashi Medical Center
- Yuta Fuyuno
- Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
- Takuto Hikichi
- Department of Endoscopy, Fukushima Medical University Hospital
- Yosuke Toya
- Division of Gastroenterology, Department of Internal Medicine, Iwate Medical University
- Kazuyuki Narimatsu
- Department of Internal Medicine, National Defense Medical College
- Noriaki Manabe
- Division of Endoscopy and Ultrasonography, Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School
- Koji Nagaike
- Department of Gastroenterology and Hepatology, Suita Municipal Hospital
- Tetsu Kinjo
- Department of Endoscopy, University of the Ryukyus Hospital
- Yorinobu Sumida
- Department of Gastroenterology, National Hospital Organization Kyushu Medical Center
- Sadahiro Funakoshi
- Department of Gastroenterological Endoscopy, Fukuoka University Hospital
- Kiyonori Kobayashi
- Department of Gastroenterology, Kitasato University, School of Medicine
- Tamotsu Matsuhashi
- Department of Gastroenterology and Neurology, Akita University Graduate School of Medicine
- Yuga Komaki
- Digestive and Lifestyle Diseases, and Hygiene and Health Promotion Medicine, Kagoshima University Graduate School of Medical and Dental Sciences
- Mitsuru Kaise
- Department of Gastroenterology, Nippon Medical School, Graduate School of Medicine
- Naoyoshi Nagata
- Department of Gastroenterological Endoscopy, Tokyo Medical University
- DOI
- https://doi.org/10.1038/s41598-024-64476-9
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 9
Abstract
Abstract The relationship between blood group and rebleeding in acute lower gastrointestinal bleeding (ALGIB) remains unclear. This study aimed to investigate the association between blood group O and clinical outcomes in patients with ALGIB. The study included 2336 patients with ALGIB whose bleeding source was identified during initial endoscopy (from the CODE BLUE-J Study). The assessed outcomes encompassed rebleeding and other clinical parameters. The rebleeding rates within 30 days in patients with blood group O and those without blood group O were 17.9% and 14.9%, respectively. Similarly, the rates within 1 year were 21.9% for patients with blood group O and 18.2% for those without blood group O. In a multivariate analysis using age, sex, vital signs at presentation, blood test findings, comorbidities, antithrombotic medication, active bleeding, and type of endoscopic treatment as covariates, patients with blood group O exhibited significantly higher risks for rebleeding within 30 days (odds ratio [OR] 1.31; 95% confidence interval [CI] 1.04–1.65; P = 0.024) and 1 year (OR 1.29; 95% CI 1.04–1.61; P = 0.020) compared to those without blood group O. However, the thrombosis and mortality rates did not differ significantly between blood group O and non-O patients. In patients with ALGIB, blood group O has been identified as an independent risk factor for both short- and long-term rebleeding.
