Nature Communications (Feb 2020)
Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway
- Hassen Kared,
- Shu Wen Tan,
- Mai Chan Lau,
- Marion Chevrier,
- Crystal Tan,
- Wilson How,
- Glenn Wong,
- Marie Strickland,
- Benoit Malleret,
- Amanda Amoah,
- Karolina Pilipow,
- Veronica Zanon,
- Naomi Mc Govern,
- Josephine Lum,
- Jin Miao Chen,
- Bernett Lee,
- Maria Carolina Florian,
- Hartmut Geiger,
- Florent Ginhoux,
- Ezequiel Ruiz-Mateos,
- Tamas Fulop,
- Reena Rajasuriar,
- Adeeba Kamarulzaman,
- Tze Pin Ng,
- Enrico Lugli,
- Anis Larbi
Affiliations
- Hassen Kared
- Singapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR)
- Shu Wen Tan
- Singapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR)
- Mai Chan Lau
- Singapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR)
- Marion Chevrier
- Singapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR)
- Crystal Tan
- Singapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR)
- Wilson How
- Singapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR)
- Glenn Wong
- Singapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR)
- Marie Strickland
- Singapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR)
- Benoit Malleret
- Singapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR)
- Amanda Amoah
- Institute of Molecular Medicine, University of Ulm
- Karolina Pilipow
- Humanitas Clinical and Research Center, Laboratory of Translational Immunology (LTI)
- Veronica Zanon
- Humanitas Clinical and Research Center, Laboratory of Translational Immunology (LTI)
- Naomi Mc Govern
- Singapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR)
- Josephine Lum
- Singapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR)
- Jin Miao Chen
- Singapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR)
- Bernett Lee
- Singapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR)
- Maria Carolina Florian
- Institute of Molecular Medicine, University of Ulm
- Hartmut Geiger
- Institute of Molecular Medicine, University of Ulm
- Florent Ginhoux
- Singapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR)
- Ezequiel Ruiz-Mateos
- Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville
- Tamas Fulop
- Department of Medicine, Faculty of Medicine, University of Sherbrooke
- Reena Rajasuriar
- Centre of Excellence for Research in AIDS (CERiA), University of Malaya
- Adeeba Kamarulzaman
- Centre of Excellence for Research in AIDS (CERiA), University of Malaya
- Tze Pin Ng
- Gerontology Research Programme and Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore
- Enrico Lugli
- Humanitas Clinical and Research Center, Laboratory of Translational Immunology (LTI)
- Anis Larbi
- Singapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR)
- DOI
- https://doi.org/10.1038/s41467-020-14442-6
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 17
Abstract
Aging is associated with immune attrition that may impact the effectiveness of the immune system to protect the host from pathogens. Here the authors show that immune aging is associated with alterations in the Wnt/β-catenin signaling and reduced stem cell memory T lymphocytes, hinting the Wnt/β-catenin pathway as a potential therapy target.
