Nanowire-Based Biosensors: From Growth to Applications
Pranav Ambhorkar,
Zongjie Wang,
Hyuongho Ko,
Sangmin Lee,
Kyo-in Koo,
Keekyoung Kim,
Dong-il (Dan) Cho
Affiliations
Pranav Ambhorkar
School of Engineering, University of British Columbia, Kelowna, BC V1V 1V7, Canada
Zongjie Wang
Department of Electrical and Computer Engineering, Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON M5S 3M2, Canada
Hyuongho Ko
Department of Electronics, Chungnam National University, Daejeon 34134, Korea
Sangmin Lee
Department of Biomedical Engineering, Kyung Hee University, Yongin 17104, Korea
Kyo-in Koo
Department of Biomedical Engineering, University of Ulsan, Ulsan 44610, Korea
Keekyoung Kim
School of Engineering, University of British Columbia, Kelowna, BC V1V 1V7, Canada
Dong-il (Dan) Cho
ASRI/ISRC, Department of Electrical and Computer Engineering, Seoul National University, Seoul 08826, Korea
Over the past decade, synthesized nanomaterials, such as carbon nanotube, nanoparticle, quantum dot, and nanowire, have already made breakthroughs in various fields, including biomedical sensors. Enormous surface area-to-volume ratio of the nanomaterials increases sensitivity dramatically compared with macro-sized material. Herein we present a comprehensive review about the working principle and fabrication process of nanowire sensor. Moreover, its applications for the detection of biomarker, virus, and DNA, as well as for drug discovery, are reviewed. Recent advances including self-powering, reusability, sensitivity in high ionic strength solvent, and long-term stability are surveyed and highlighted as well. Nanowire is expected to lead significant improvement of biomedical sensor in the near future.
