Nature Communications (Jun 2021)
A single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centre
- Matteo A. Molè,
- Tim H. H. Coorens,
- Marta N. Shahbazi,
- Antonia Weberling,
- Bailey A. T. Weatherbee,
- Carlos W. Gantner,
- Carmen Sancho-Serra,
- Lucy Richardson,
- Abbie Drinkwater,
- Najma Syed,
- Stephanie Engley,
- Philip Snell,
- Leila Christie,
- Kay Elder,
- Alison Campbell,
- Simon Fishel,
- Sam Behjati,
- Roser Vento-Tormo,
- Magdalena Zernicka-Goetz
Affiliations
- Matteo A. Molè
- Department of Physiology, Development and Neuroscience, Mammalian Embryo and Stem Cell Group, University of Cambridge
- Tim H. H. Coorens
- Wellcome Sanger Institute
- Marta N. Shahbazi
- Department of Physiology, Development and Neuroscience, Mammalian Embryo and Stem Cell Group, University of Cambridge
- Antonia Weberling
- Department of Physiology, Development and Neuroscience, Mammalian Embryo and Stem Cell Group, University of Cambridge
- Bailey A. T. Weatherbee
- Department of Physiology, Development and Neuroscience, Mammalian Embryo and Stem Cell Group, University of Cambridge
- Carlos W. Gantner
- Department of Physiology, Development and Neuroscience, Mammalian Embryo and Stem Cell Group, University of Cambridge
- Carmen Sancho-Serra
- Wellcome Sanger Institute
- Lucy Richardson
- Herts & Essex Fertility Centre, Bishops College
- Abbie Drinkwater
- Herts & Essex Fertility Centre, Bishops College
- Najma Syed
- Herts & Essex Fertility Centre, Bishops College
- Stephanie Engley
- Herts & Essex Fertility Centre, Bishops College
- Philip Snell
- Bourn Hall
- Leila Christie
- Bourn Hall
- Kay Elder
- Bourn Hall
- Alison Campbell
- CARE Fertility Group
- Simon Fishel
- CARE Fertility Group
- Sam Behjati
- Wellcome Sanger Institute
- Roser Vento-Tormo
- Wellcome Sanger Institute
- Magdalena Zernicka-Goetz
- Department of Physiology, Development and Neuroscience, Mammalian Embryo and Stem Cell Group, University of Cambridge
- DOI
- https://doi.org/10.1038/s41467-021-23758-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
Single cell analysis of early human embryos identifies key changes in pluripotency, the requirement of FGF signalling for embryo survival, and defines a putative anterior-like region of hypoblast cells, providing insights into how early human development is regulated.
