Nature Communications (May 2022)
The 3′ Pol II pausing at replication-dependent histone genes is regulated by Mediator through Cajal bodies’ association with histone locus bodies
- Hidefumi Suzuki,
- Ryota Abe,
- Miho Shimada,
- Tomonori Hirose,
- Hiroko Hirose,
- Keisuke Noguchi,
- Yoko Ike,
- Nanami Yasui,
- Kazuki Furugori,
- Yuki Yamaguchi,
- Atsushi Toyoda,
- Yutaka Suzuki,
- Tatsuro Yamamoto,
- Noriko Saitoh,
- Shigeo Sato,
- Chieri Tomomori-Sato,
- Ronald C. Conaway,
- Joan W. Conaway,
- Hidehisa Takahashi
Affiliations
- Hidefumi Suzuki
- Department of Molecular Biology, Yokohama City University Graduate School of Medical Science
- Ryota Abe
- Department of Molecular Biology, Yokohama City University Graduate School of Medical Science
- Miho Shimada
- Department of Molecular Biology, Yokohama City University Graduate School of Medical Science
- Tomonori Hirose
- Department of Molecular Biology, Yokohama City University Graduate School of Medical Science
- Hiroko Hirose
- Department of Molecular Biology, Yokohama City University Graduate School of Medical Science
- Keisuke Noguchi
- Department of Molecular Biology, Yokohama City University Graduate School of Medical Science
- Yoko Ike
- Department of Molecular Biology, Yokohama City University Graduate School of Medical Science
- Nanami Yasui
- Department of Molecular Biology, Yokohama City University Graduate School of Medical Science
- Kazuki Furugori
- Department of Molecular Biology, Yokohama City University Graduate School of Medical Science
- Yuki Yamaguchi
- School of Life Science and Technology, Tokyo Institute of Technology
- Atsushi Toyoda
- Comparative Genomics Laboratory, National Institute of Genetics
- Yutaka Suzuki
- Laboratory of Systems Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo
- Tatsuro Yamamoto
- Division of Cancer Biology, The Cancer Institute of JFCR
- Noriko Saitoh
- Division of Cancer Biology, The Cancer Institute of JFCR
- Shigeo Sato
- Stowers Institute for Medical Research
- Chieri Tomomori-Sato
- Stowers Institute for Medical Research
- Ronald C. Conaway
- Stowers Institute for Medical Research
- Joan W. Conaway
- Stowers Institute for Medical Research
- Hidehisa Takahashi
- Department of Molecular Biology, Yokohama City University Graduate School of Medical Science
- DOI
- https://doi.org/10.1038/s41467-022-30632-w
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 24
Abstract
Transcription termination is generally accompanied by the 3′-end processing of transcripts. Here the authors demonstrate a role for Mediator in transcript end site proximal pausing of replication-dependent histone genes.
