Diabetes, Metabolic Syndrome and Obesity (Sep 2021)
Association Between Blood Pressure and Branched-Chain/Aromatic Amino Acid Excretion Rate in 24-Hour Urine Samples from Elderly Hypertension Patients
Abstract
Faxuan Wang,1,2,* Binxia Wang,3,* Xiyuan Chen,1,2 Wanlu Liu,1,2 Guoqi Wang,1,2 Xiaoxia Li,1,2 Xiuying Liu,1,2 Nan Li,1,2 Jiaxing Zhang,1,2 Ting Yin,1,2 Jinyun Jing,1,2 Xiaoyu Chang,4 Yanan Jin,5 Yuhong Zhang,1,2 Yi Zhao1 1School of Public Health and Management, Ningxia Medical University, Yinchuan, Ningxia, People’s Republic of China; 2Key Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan, Ningxia, People’s Republic of China; 3Second People’s Hospital of Gansu Province, Lanzhou, Gansu, People’s Republic of China; 4Editorial Department of the Journal of Ningxia Medical University, Ningxia Medical University, Yinchuan, Ningxia, People’s Republic of China; 5Centers for Disease Control and Prevention in Ningxia, Yinchuan, Ningxia, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yi ZhaoSchool of Public Health and Management, Ningxia Medical University Tel +86 139 9501 1690Fax +86 951-6980144Email [email protected]: Recently, the association between lifestyle-related diseases and free amino acids in the blood plasma—especially branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs)—has been highlighted. However, few studies have been carried out on 24-hour urine samples. Therefore, we aimed to explore the relationships between 24-hour urinary BCAAs and AAAs excretion rate and blood pressure (BP) in elderly patients with hypertension.Methods and Results: Each of the 322 elderly patients with hypertension completed an in-person questionnaire interview, underwent a physical examination, and provided a 24-hour urine specimen. We measured their BCAAs and AAAs excretion rate, and used multiple linear regression analysis with variable selection to construct models describing the relationships between their BCAAs and AAAs excretion rate and BP. After adjusted for age, gender, height, and weight, valine was inversely associated with both systolic blood pressure (SBP) (β: − 0.232, 95% CI: − 0.16, − 0.006) and diastolic blood pressure (DBP) (β: − 0.144, 95% CI: − 0.089, − 0.005). These findings were invariant even following adjustment for urine volume and drugs history, and Ile was positively associated with DBP (β: 0.170, 95% CI: 0.001, 0.066).Conclusion: The data revealed that the excretion rate of 24-hour urinary BCAAs was closely related to BP in elderly hypertension patients, and these findings will provide new insights into the association between BACC metabolism and BP.Keywords: hypertension, branched-chain amino acid, aromatic amino acid, association
