Microwave assisted synthesis of phenanthridine derivatives via Suzuki coupling and condensation

Abstract

One-pot synthesis of phenanthridine derivatives using appropriately substituted aromatic ortho-bromo N-tosylhydrazones and 2′-aminobenzeneboronic acid pinacol esters is described. In the presence of Pd(amphos)Cl2 catalyst, tosylhydrazone precursors undergo a Suzuki cross-coupling reaction with 2′-aminobenzeneboronic acid pinacol ester derivatives followed by intramolecular condensation to form the corresponding phenanthridines derivatives in one step.

Keywords

• Phenanthridines
• Tosylhydrazones
• 2′-aminophenylboronic acid pinacol esters
• Suzuki coupling
• Condensation reaction
• One pot synthesis