Discovery of Novel Naphthoquinone–Chalcone Hybrids as Potent FGFR1 Tyrosine Kinase Inhibitors: Synthesis, Biological Evaluation, and Molecular Modeling

• Ronnakorn Leechaisit,
• Panupong Mahalapbutr,
• Pornthip Boonsri,
• Kun Karnchanapandh,
• Thanyada Rungrotmongkol,
• Veda Prachayasittikul,
• Supaluk Prachayasittikul,
• Somsak Ruchirawat,
• Virapong Prachayasittikul,
• Ratchanok Pingaew

Affiliations

Ronnakorn Leechaisit

Department of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok, Thailand

Panupong Mahalapbutr

Department of Biochemistry, Center for Translational Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand

Pornthip Boonsri

Department of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok, Thailand

Kun Karnchanapandh

Program in Bioinformatics and Computational Biology, Graduate School, Chulalongkorn University, Bangkok, Thailand

Thanyada Rungrotmongkol

Program in Bioinformatics and Computational Biology, Graduate School, Chulalongkorn University, Bangkok, Thailand

Veda Prachayasittikul

Center for Research Innovation and Biomedical Informatics, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand

Supaluk Prachayasittikul

Center for Research Innovation and Biomedical Informatics, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand

Somsak Ruchirawat

Laboratory of Medicinal Chemistry, Chulabhorn Research Institute, Bangkok, Thailand

Virapong Prachayasittikul

Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand

Ratchanok Pingaew

Department of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok, Thailand