Arkadia/RNF111 is a SUMO-targeted ubiquitin ligase with preference for substrates marked with SUMO1-capped SUMO2/3 chain

Annie M. Sriramachandran; Katrin Meyer-Teschendorf; Stefan Pabst; Helle D. Ulrich; Niels H. Gehring; Kay Hofmann; Gerrit J. K. Praefcke; R. Jürgen Dohmen

doi:10.1038/s41467-019-11549-3

Nature Communications (Aug 2019)

Arkadia/RNF111 is a SUMO-targeted ubiquitin ligase with preference for substrates marked with SUMO1-capped SUMO2/3 chain

Annie M. Sriramachandran,
Katrin Meyer-Teschendorf,
Stefan Pabst,
Helle D. Ulrich,
Niels H. Gehring,
Kay Hofmann,
Gerrit J. K. Praefcke,
R. Jürgen Dohmen

Affiliations

Annie M. Sriramachandran: Institute for Genetics, Faculty of Mathematics and Natural Sciences, University of Cologne, Center of Molecular Biosciences
Katrin Meyer-Teschendorf: Institute for Genetics, Faculty of Mathematics and Natural Sciences, University of Cologne, Center of Molecular Biosciences
Stefan Pabst: Institute for Genetics, Faculty of Mathematics and Natural Sciences, University of Cologne, Center of Molecular Biosciences
Helle D. Ulrich: Institute of Molecular Biology
Niels H. Gehring: Institute for Genetics, Faculty of Mathematics and Natural Sciences, University of Cologne, Center of Molecular Biosciences
Kay Hofmann: Institute for Genetics, Faculty of Mathematics and Natural Sciences, University of Cologne, Center of Molecular Biosciences
Gerrit J. K. Praefcke: Institute for Genetics, Faculty of Mathematics and Natural Sciences, University of Cologne, Center of Molecular Biosciences
R. Jürgen Dohmen: Institute for Genetics, Faculty of Mathematics and Natural Sciences, University of Cologne, Center of Molecular Biosciences

DOI: https://doi.org/10.1038/s41467-019-11549-3
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 12

Abstract

Read online

The cellular functions of poly-SUMO chains of different compositions are not fully understood. Here, the authors characterize Arkadia/RNF111 as a SUMO-targeted ubiquitin ligase that recognizes proteins with hybrid SUMO1-capped SUMO2/3 chains and targets them for proteasomal degradation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal