Cancer Predisposition Syndromes Associated With Pediatric High-Grade Gliomas

Giulia Ceglie; Giada Del Baldo; Emanuele Agolini; Martina Rinelli; Antonella Cacchione; Francesca Del Bufalo; Maria Vinci; Roberto Carta; Luigi Boccuto; Luigi Boccuto; Evelina Miele; Angela Mastronuzzi; Franco Locatelli; Franco Locatelli; Andrea Carai

doi:10.3389/fped.2020.561487

Frontiers in Pediatrics (Nov 2020)

Cancer Predisposition Syndromes Associated With Pediatric High-Grade Gliomas

Giulia Ceglie,
Giada Del Baldo,
Emanuele Agolini,
Martina Rinelli,
Antonella Cacchione,
Francesca Del Bufalo,
Maria Vinci,
Roberto Carta,
Luigi Boccuto,
Luigi Boccuto,
Evelina Miele,
Angela Mastronuzzi,
Franco Locatelli,
Franco Locatelli,
Andrea Carai

Affiliations

Giulia Ceglie: Department of Pediatric Hematology/Oncology and Cell and Gene Therapy, Istituto di Ricovero e Cura a Carattere Scientifico Bambino Gesù Children's Hospital, Rome, Italy
Giada Del Baldo: Department of Pediatric Hematology/Oncology and Cell and Gene Therapy, Istituto di Ricovero e Cura a Carattere Scientifico Bambino Gesù Children's Hospital, Rome, Italy
Emanuele Agolini: Laboratory of Medical Genetics, Istituto di Ricovero e Cura a Carattere Scientifico Bambino Gesù Children's Hospital, Rome, Italy
Martina Rinelli: Laboratory of Medical Genetics, Istituto di Ricovero e Cura a Carattere Scientifico Bambino Gesù Children's Hospital, Rome, Italy
Antonella Cacchione: Department of Pediatric Hematology/Oncology and Cell and Gene Therapy, Istituto di Ricovero e Cura a Carattere Scientifico Bambino Gesù Children's Hospital, Rome, Italy
Francesca Del Bufalo: Department of Pediatric Hematology/Oncology and Cell and Gene Therapy, Istituto di Ricovero e Cura a Carattere Scientifico Bambino Gesù Children's Hospital, Rome, Italy
Maria Vinci: Department of Pediatric Hematology/Oncology and Cell and Gene Therapy, Istituto di Ricovero e Cura a Carattere Scientifico Bambino Gesù Children's Hospital, Rome, Italy
Roberto Carta: Department of Pediatric Hematology/Oncology and Cell and Gene Therapy, Istituto di Ricovero e Cura a Carattere Scientifico Bambino Gesù Children's Hospital, Rome, Italy
Luigi Boccuto: Greenwood Genetic Center, Greenwood, SC, United States
Luigi Boccuto: Clemson University School of Health Research, Clemson, SC, United States
Evelina Miele: Department of Pediatric Hematology/Oncology and Cell and Gene Therapy, Istituto di Ricovero e Cura a Carattere Scientifico Bambino Gesù Children's Hospital, Rome, Italy
Angela Mastronuzzi: Department of Pediatric Hematology/Oncology and Cell and Gene Therapy, Istituto di Ricovero e Cura a Carattere Scientifico Bambino Gesù Children's Hospital, Rome, Italy
Franco Locatelli: Department of Pediatric Hematology/Oncology and Cell and Gene Therapy, Istituto di Ricovero e Cura a Carattere Scientifico Bambino Gesù Children's Hospital, Rome, Italy
Franco Locatelli: Sapienza, University of Rome, Rome, Italy
Andrea Carai: Neurosurgery Unit, Department of Neurological and Psychiatric Sciences, Istituto di Ricovero e Cura a Carattere Scientifico Bambino Gesù Children's Hospital, Rome, Italy

DOI: https://doi.org/10.3389/fped.2020.561487
Journal volume & issue: Vol. 8

Abstract

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Pediatric High-Grade Gliomas (pHGG) are among the deadliest childhood brain tumors and can be associated with an underlying cancer predisposing syndrome. The thorough understanding of these syndromes can aid the clinician in their prompt recognition, leading to an informed genetic counseling for families and to a wider understanding of a specific genetic landscape of the tumor for target therapies. In this review, we summarize the main pHGG-associated cancer predisposing conditions, providing a guide for suspecting these syndromes and referring for genetic counseling.

Published in Frontiers in Pediatrics

ISSN: 2296-2360 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Pediatrics
Website: http://journal.frontiersin.org/journal/pediatrics

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