Nature Communications (Jul 2019)

Acetylation regulates ribonucleotide reductase activity and cancer cell growth

  • Guo Chen,
  • Yin Luo,
  • Kurt Warncke,
  • Youwei Sun,
  • David S. Yu,
  • Haian Fu,
  • Madhusmita Behera,
  • Suresh S. Ramalingam,
  • Paul W. Doetsch,
  • Duc M. Duong,
  • Michael Lammers,
  • Walter J. Curran,
  • Xingming Deng

DOI
https://doi.org/10.1038/s41467-019-11214-9
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 16

Abstract

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Ribonucleotide reductase (RNR) catalyzes the de novo synthesis of deoxyribonucleoside diphosphates to provide dNTP precursors for DNA synthesis. Here the authors show that the availability of dNTPs, DNA replication, and cellular proliferation, are modulated by acetylation and deacetylation of RRM2 by KAT7 and Sirt2 respectively.