PLoS ONE (Jan 2018)

Independent association of HLA-DPB1*02:01 with rheumatoid arthritis in Japanese populations.

  • Hiroshi Furukawa,
  • Shomi Oka,
  • Kota Shimada,
  • Atsushi Hashimoto,
  • Akiko Komiya,
  • Shinichiro Tsunoda,
  • Akiko Suda,
  • Satoshi Ito,
  • Koichiro Saisho,
  • Masao Katayama,
  • Satoshi Shinohara,
  • Takeo Sato,
  • Katsuya Nagatani,
  • Seiji Minota,
  • Toshihiro Matsui,
  • Naoshi Fukui,
  • Shoji Sugii,
  • Hajime Sano,
  • Kiyoshi Migita,
  • Shouhei Nagaoka,
  • Shigeto Tohma

DOI
https://doi.org/10.1371/journal.pone.0204459
Journal volume & issue
Vol. 13, no. 9
p. e0204459

Abstract

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OBJECTIVE:Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized with joint destructions; environmental and genetic factors were thought to be involved in the etiology of RA. The production of anti-citrullinated peptide antibodies (ACPA) is specifically associated with RA. DRB1 is associated with the susceptibility of RA, especially ACPA-positive RA [ACPA(+)RA]. However, a few studies reported on the independent associations of DPB1 alleles with RA susceptibility. Thus, we investigated the independent association of DPB1 alleles with RA in Japanese populations. METHODS:Association analyses of DPB1 were conducted by logistic regression analysis in 1667 RA patients and 413 controls. RESULTS:In unconditioned analysis, DPB1*04:02 was nominally associated with the susceptibility of ACPA(+)RA (P = 0.0021, corrected P (Pc) = 0.0275, odds ratio [OR] 1.52, 95% confidence interval [CI] 1.16-1.99). A significant association of DPB1*02:01 with the susceptibility of ACPA(+)RA was observed, when conditioned on DRB1 (Padjusted = 0.0003, Pcadjusted = 0.0040, ORadjusted 1.47, 95%CI 1.19-1.81). DPB1*05:01 was tended to be associated with the protection against ACPA(+)RA, when conditioned on DRB1 (Padjusted = 0.0091, Pcadjusted = 0.1184, ORadjusted 0.78, 95%CI 0.65-0.94). When conditioned on DRB1, the association of DPB1*04:02 with ACPA(+)RA was disappeared. No association of DPB1 alleles with ACPA-negative RA was detected. CONCLUSION:The independent association of DPB1*02:01 with Japanese ACPA(+)RA was identified.