Nature Communications (Dec 2019)
Gut uropathogen abundance is a risk factor for development of bacteriuria and urinary tract infection
- Matthew Magruder,
- Adam N. Sholi,
- Catherine Gong,
- Lisa Zhang,
- Emmanuel Edusei,
- Jennifer Huang,
- Shady Albakry,
- Michael J. Satlin,
- Lars F. Westblade,
- Carl Crawford,
- Darshana M. Dadhania,
- Michelle Lubetzky,
- Ying Taur,
- Eric Littman,
- Lilan Ling,
- Philip Burnham,
- Iwijn De Vlaminck,
- Eric Pamer,
- Manikkam Suthanthiran,
- John Richard Lee
Affiliations
- Matthew Magruder
- Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine
- Adam N. Sholi
- Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine
- Catherine Gong
- Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine
- Lisa Zhang
- Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine
- Emmanuel Edusei
- Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine
- Jennifer Huang
- Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine
- Shady Albakry
- Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine
- Michael J. Satlin
- Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine
- Lars F. Westblade
- Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine
- Carl Crawford
- Division of Gastroenterology, Department of Medicine, Weill Cornell Medicine
- Darshana M. Dadhania
- Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine
- Michelle Lubetzky
- Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine
- Ying Taur
- Infectious Disease Services, Department of Medicine, Memorial Sloan Kettering Cancer Center
- Eric Littman
- Infectious Disease Services, Department of Medicine, Memorial Sloan Kettering Cancer Center
- Lilan Ling
- Infectious Disease Services, Department of Medicine, Memorial Sloan Kettering Cancer Center
- Philip Burnham
- Department of Biomedical Engineering, Cornell University
- Iwijn De Vlaminck
- Department of Biomedical Engineering, Cornell University
- Eric Pamer
- Infectious Disease Services, Department of Medicine, Memorial Sloan Kettering Cancer Center
- Manikkam Suthanthiran
- Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine
- John Richard Lee
- Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine
- DOI
- https://doi.org/10.1038/s41467-019-13467-w
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 9
Abstract
Urinary tract infections (UTIs) are associated with changes in the gut microbiome. Here, the authors evaluate the relationship between the gut microbiome and development of UTI in kidney transplant patients and show that uropathogenic gut abundance might represent a risk factor for development of bacteriuria and UTI.
