Nature Communications (Jun 2017)

A robot for high yield electrophysiology and morphology of single neurons in vivo

  • Lu Li,
  • Benjamin Ouellette,
  • William A. Stoy,
  • Emma J. Garren,
  • Tanya L. Daigle,
  • Craig R. Forest,
  • Christof Koch,
  • Hongkui Zeng

DOI
https://doi.org/10.1038/ncomms15604
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 10

Abstract

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Single-cell characterization and perturbation of neurons is critical for revealing the structure-function relationship of brain cells. Here the authors develop a robot that performs single-cell electroporation and extracellular electrophysiology and can be used for performingin vivosingle-cell experiments in deep brain tissues optically difficult to access.