TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription

Fernando Gómez-Herreros; Guido Zagnoli-Vieira; Ioanna Ntai; María Isabel Martínez-Macías; Rhona M. Anderson; Andrés Herrero-Ruíz; Keith W. Caldecott

doi:10.1038/s41467-017-00307-y

Nature Communications (Aug 2017)

TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription

Fernando Gómez-Herreros,
Guido Zagnoli-Vieira,
Ioanna Ntai,
María Isabel Martínez-Macías,
Rhona M. Anderson,
Andrés Herrero-Ruíz,
Keith W. Caldecott

Affiliations

Fernando Gómez-Herreros: Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer
Guido Zagnoli-Vieira: Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer
Ioanna Ntai: Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer
María Isabel Martínez-Macías: Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer
Rhona M. Anderson: Institute of Environment, Health and Societies, Brunel University London
Andrés Herrero-Ruíz: Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer
Keith W. Caldecott: Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer

DOI: https://doi.org/10.1038/s41467-017-00307-y
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 9

Abstract

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DNA double-strand breaks (DSBs) induced by topoisomerase II (TOP2) are rejoined by TDP2-dependent non-homologous end-joining (NHEJ) but whether this promotes or suppresses translocations is not clear. Here the authors show that TDP2 suppresses chromosome translocations from DSBs introduced during gene transcription.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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