Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya Str., 16/10, 117997 Moscow, Russia
Yulia E. Vinogradova
Department of Hospital Therapy No. 2, Sechenov University (I.M. Sechenov First Moscow State Medical University), 8 Trubetskaya Str., Building 2, 119991 Moscow, Russia
Dmitry L. Vinogradov
Department of Hospital Therapy No. 2, Sechenov University (I.M. Sechenov First Moscow State Medical University), 8 Trubetskaya Str., Building 2, 119991 Moscow, Russia
Marina S. Krasilshchikova
Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya Str., 16/10, 117997 Moscow, Russia
Vadim T. Ivanov
Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya Str., 16/10, 117997 Moscow, Russia
The paper summarizes the available information concerning the biological properties and biomedical applications of Thymodepressin. This synthetic peptide drug displays pronounced immunoinhibitory activity across a wide range of conditions in vitro and in vivo. The history of its unforeseen discovery is briefly reviewed, and the current as well as potential expansion areas of medicinal practice are outlined. Additional experimental evidence is obtained, demonstrating several potential advantages of Thymodepressin over another actively used immunosuppressor drug, cyclosporin A.
