Scientific Reports (Apr 2017)

Cadmium exposure and its association with serum uric acid and hyperuricemia

  • Honglin Sun,
  • Ningjian Wang,
  • Chi Chen,
  • Xiaomin Nie,
  • Bing Han,
  • Qin Li,
  • Chunfang Zhu,
  • Yi Chen,
  • Fangzhen Xia,
  • Yingchao Chen,
  • Hualing Zhai,
  • Boren Jiang,
  • Bin Hu,
  • Yingli Lu

DOI
https://doi.org/10.1038/s41598-017-00661-3
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 8

Abstract

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Abstract Few studies have investigated the association between serum uric acid (UA) and cadmium exposure. Our previous study revealed a significantly higher blood cadmium (CdB) level in the Chinese population compared to populations in other countries. To determine whether CdB in Chinese adults is associated with serum UA and hyperuricemia, 2996 participants from the cross-sectional SPECT-China study were recruited. CdB was measured by atomic absorption spectrometry. Hyperuricemia was defined as a serum UA concentration ≥416.4 μmol/L for men and ≥356.9 μmol/L for women. Regression analyses were used to analyze the association of CdB with serum UA and hyperuricemia. We found that the median CdB level was higher in men with hyperuricemia (2.40 μg/L) than in men without hyperuricemia (1.98 μg/L, P 60 mL/min per 1.73 m2. Further, the odds ratio of hyperuricemia increased with increasing CdB quartiles (P for trend < 0.05) in men. In conclusion, CdB was positively related to the serum UA level and to hyperuricemia in Chinese men but not in Chinese women.